Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer's disease on A beta 1-40 peptide early assembly

Serena Lazzaro, Nina Ogrinc, Lieke Lamont, Graziella Vecchio, Giuseppe Pappalardo, Ron M. A. Heeren*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)6353-6363
Number of pages11
JournalAnalytical and Bioanalytical Chemistry
Volume411
Issue number24
DOIs
Publication statusPublished - Sep 2019

Keywords

  • Alzheimer's disease (AD)
  • Amyloid beta-peptide oligomers
  • Electrospray ionization-ion mobility-mass spectrometry (ESI-IM-MS)
  • Multivariate statistical analysis (MVA)
  • AMYLOID-BETA-PROTEIN
  • MASS-SPECTROMETRY
  • NEURODEGENERATIVE DISEASES
  • PERSONALIZED MEDICINE
  • OXIDATION
  • POLYMORPHISM
  • AGGREGATION
  • INHIBITORS
  • STRATEGIES
  • OLIGOMERS

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