Investigating human neocortical architecture in 3D: new approaches for clearing, labelling and imaging large samples

Sven Hildebrand

doi:10.26481/dis.20211214sh

Investigating human neocortical architecture in 3D: new approaches for clearing, labelling and imaging large samples

Sven Hildebrand

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

By turning human brain tissue as transparent as glass, the brain’s complex structure can be studied in 3D. This is possible by imaging these very large, transparent samples with a special microscope that can quickly scan huge tissue volumes. By doing so, it was possible to visualise different components of the human neocortex, the most recent and most complex add-on to the brain during evolution.

Original language	English
Awarding Institution	Maastricht University
Supervisors/Advisors	Roebroeck, Alard, Supervisor Goebel, Rainer, Supervisor Galuske, Ralf A.W., Co-Supervisor, External person
Award date	14 Dec 2021
Place of Publication	Maastricht
Publisher	Maastricht University
Print ISBNs	9789464235920
DOIs	https://doi.org/10.26481/dis.20211214sh
Publication status	Published - 2021

Keywords

human brain
optical tissue clearing
light-sheet fluorescent microscopy
neuroanatomy

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10.26481/dis.20211214sh

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Cite this

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AB - By turning human brain tissue as transparent as glass, the brain’s complex structure can be studied in 3D. This is possible by imaging these very large, transparent samples with a special microscope that can quickly scan huge tissue volumes. By doing so, it was possible to visualise different components of the human neocortex, the most recent and most complex add-on to the brain during evolution.

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KW - optical tissue clearing

KW - light-sheet fluorescent microscopy

KW - neuroanatomy

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U2 - 10.26481/dis.20211214sh

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ER -

Investigating human neocortical architecture in 3D: new approaches for clearing, labelling and imaging large samples

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Keywords

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