Investigating human neocortical architecture in 3D: new approaches for clearing, labelling and imaging large samples

Research output: ThesisDoctoral ThesisInternal

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By turning human brain tissue as transparent as glass, the brain’s complex structure can be studied in 3D. This is possible by imaging these very large, transparent samples with a special microscope that can quickly scan huge tissue volumes. By doing so, it was possible to visualise different components of the human neocortex, the most recent and most complex add-on to the brain during evolution.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Roebroeck, Alard, Supervisor
  • Goebel, Rainer, Supervisor
  • Galuske, Ralf A.W., Co-Supervisor, External person
Award date14 Dec 2021
Place of PublicationMaastricht
Print ISBNs9789464235920
Publication statusPublished - 2021


  • human brain
  • optical tissue clearing
  • light-sheet fluorescent microscopy
  • neuroanatomy

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