Inverse remodelling of K(2P)3.1 K(+) channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy

Constanze Schmidt, Felix Wiedmann, Xiao-Bo Zhou, Jordi Heijman, Niels Voigt, Antonius Ratte, Siegfried Lang, Stefan M. Kallenberger, Chiara Campana, Alexander Weymann, Raffaele De Simone, Gabor Szabo, Arjang Ruhparwar, Klaus Kallenbach, Matthias Karck, Joachim R. Ehrlich, Istvan Baczko, Martin Borggrefe, Ursula Ravens, Dobromir DobrevHugo A. Katus, Dierk Thomas*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1764-1774
Number of pages11
JournalEuropean Heart Journal
Volume38
Issue number22
DOIs
Publication statusPublished - 7 Jun 2017

Keywords

  • Arrhythmia
  • Atrial fibrillation
  • Electrical remodelling
  • Electrophysiology
  • Heart failure
  • K(2P)3.1 channel
  • HEART-FAILURE
  • UP-REGULATION
  • MODEL
  • SUPPRESSION
  • TACHYCARDIA
  • MECHANISMS

Cite this

Schmidt, C., Wiedmann, F., Zhou, X-B., Heijman, J., Voigt, N., Ratte, A., Lang, S., Kallenberger, S. M., Campana, C., Weymann, A., De Simone, R., Szabo, G., Ruhparwar, A., Kallenbach, K., Karck, M., Ehrlich, J. R., Baczko, I., Borggrefe, M., Ravens, U., ... Thomas, D. (2017). Inverse remodelling of K(2P)3.1 K(+) channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy. European Heart Journal, 38(22), 1764-1774. https://doi.org/10.1093/eurheartj/ehw559