Invasive neurophysiological recordings in human basal ganglia. What have we learned about non-motor behaviour?

Ana Maria Alzate Sanchez, Mark J. Roberts, Yasin Temel, Marcus L. F. Janssen*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Research into the function of deep brain structures has benefited greatly from microelectrode recordings in animals. This has helped to unravel physiological processes in the healthy and malfunctioning brain. Translation to the human is necessary for improving basic understanding of subcortical structures and their implications in diseases. The use of microelectrode recordings as a standard component of deep brain stimulation surgery offers the most viable route for studying the electrophysiology of single cells and local neuronal populations in important deep structures of the human brain. Most of the studies in the basal ganglia have targeted the motor loop and movement disorder pathophysiology. In recent years, however, research has diversified to include limbic and cognitive processes. This review aims to provide an overview of advances in neuroscience made using intraoperative and post-operative recordings with a focus on non-motor activity in the basal ganglia.Research into deep brain structures, through microelectrode recordings (MER) in animals, has advanced our understanding of physiological processes in both healthy and diseased brains. Translating these findings to humans is essential for furthering knowledge of subcortical structures and their role in disease. Most of the studies in the basal ganglia have targeted the motor loop; however, recent research has diversified to include limbic and cognitive processes, like reward, decision-making and emotional processing. image
Original languageEnglish
Pages (from-to)6145-6159
Number of pages15
JournalEuropean Journal of Neuroscience
Volume60
Issue number9
DOIs
Publication statusPublished - Nov 2024

Keywords

  • basal ganglia
  • electrophysiology
  • human research
  • intraoperative recordings
  • non-motor activity
  • post-operative recordings
  • HUMAN SUBTHALAMIC NUCLEUS
  • OBSESSIVE-COMPULSIVE DISORDER
  • HIGH-FREQUENCY STIMULATION
  • GLOBUS-PALLIDUS INTERNUS
  • PARKINSONS-DISEASE
  • REWARD
  • IDENTIFICATION
  • OSCILLATIONS
  • NEURONS
  • MOTOR

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