Introducing height to mechanobiology: A tissue engineering perspective

Jip Zonderland

Research output: ThesisDoctoral ThesisInternal

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Abstract

Cell behavior is relatively well studied in 2D petridishes, but not in a 3D environment. Increasing evidence shows a large difference in cell behavior in 3D vs 2D. This thesis is focussed on exploring the extent and consequences of these differences in tissue stiff engineering scaffolds. A large influence of the 3D environment on mechanobiological proteins was found and it was shown that these proteins have a different role in 3D than in 2D. On top of this, several novel scaffolds were developed that can help to advance 3D biological research.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Moroni, Lorenzo, Supervisor
  • van Blitterswijk, Clemens, Advisor
Award date1 Jul 2020
Place of PublicationMaastricht
Publisher
Print ISBNs9789463808347
DOIs
Publication statusPublished - 2020

Keywords

  • Mechanobiology
  • tissue engineering
  • regenerative medicine
  • 3D printing
  • 3D biology
  • cytoskeleton

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