Abstract
Cell behavior is relatively well studied in 2D petridishes, but not in a 3D environment. Increasing evidence shows a large difference in cell behavior in 3D vs 2D. This thesis is focussed on exploring the extent and consequences of these differences in tissue stiff engineering scaffolds. A large influence of the 3D environment on mechanobiological proteins was found and it was shown that these proteins have a different role in 3D than in 2D. On top of this, several novel scaffolds were developed that can help to advance 3D biological research.
Original language | English |
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Awarding Institution |
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Supervisors/Advisors |
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Award date | 1 Jul 2020 |
Place of Publication | Maastricht |
Publisher | |
Print ISBNs | 9789463808347 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- Mechanobiology
- tissue engineering
- regenerative medicine
- 3D printing
- 3D biology
- cytoskeleton