Intrinsic functional architecture of the macaque dorsal and ventral lateral frontal cortex

Alexandros Goulas, Peter Stiers, R Matthew Hutchison, Stefan Everling, Michael Petrides, Daniel S Margulies

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Investigations of the cellular and connectional organization of the lateral frontal cortex (LFC) of the macaque monkey provide indispensable knowledge for generating hypotheses about the human LFC. However, despite numerous investigations, there are still debates on the organization of this brain region. In vivo neuroimaging techniques such as resting-state fMRI can be used to define the functional circuitry of brain areas producing results largely consistent with gold-standard invasive tract-tracing techniques and offering the opportunity for cross-species comparison within the same modality. Our results using resting-state fMRI from macaque monkeys to uncover the intrinsic functional architecture of the LFC corroborate previous findings and inform current debates. Specifically, we show that i) the region in the midline and anterior to the superior arcuate sulcus is divided in two areas separated by the posterior supraprincipal dimple; ii) the cytoarchitectonically defined area 6DC/F2 contains two connectional divisions; and, iii) a distinct area occupies the cortex around the spur of the arcuate, updating what was previously proposed to be the border between dorsal and ventral motor/premotor areas. Within the ventral LFC specifically, the derived parcellation clearly suggests the presence of distinct areas i) with a somatomotor/orofacial connectional signature (putative area 44), ii) with an occulomotor connectional signature (putative frontal eye fields), and iii) premotor areas possibly hosting laryngeal and arm representations. Our results illustrate in detail the intrinsic functional architecture of the macaque LFC, thus providing valuable evidence for debates on its organization.

Original languageEnglish
Pages (from-to)1084-1099
Number of pages16
JournalJournal of Neurophysiology
Volume117
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • cortical areas
  • in vivo parcellation
  • functional connectivity
  • premotor
  • prefrontal
  • COMPARATIVE CYTOARCHITECTONIC ANALYSIS
  • CORTICOCORTICAL CONNECTION PATTERNS
  • VENTROLATERAL PREFRONTAL CORTEX
  • RESTING-STATE FMRI
  • RHESUS-MONKEY
  • CORTICAL CONNECTIONS
  • PREMOTOR CORTEX
  • EYE FIELDS
  • PARIETAL CORTEX
  • PARCELLATION SCHEME

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