Intravital imaging of phagocyte recruitment

Remco T. A. Megens*, Klaus Kemmerich, Juergen Pyta, Christian Weber, Oliver Soehnlein

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Web of Science)

Abstract

Extravasation of neutrophils and monocytes is a hallmark event in acute and chronic inflammation. Owing to recent improvements in optical imaging techniques, the classical leukocyte extravasation cascade has been refined with intermediate steps being added. Further studies have shown tissue specific leukocyte recruitment patterns, thus allowing for more selective targeting. Here we focus on recent advances in intravital imaging of leukocyte recruitment by means of optical imaging techniques and emphasise the translation thereof into tissue-specific recruitment to the lungs, the liver and large arteries.
Original languageEnglish
Pages (from-to)802-810
JournalThrombosis and Haemostasis
Volume105
Issue number5
DOIs
Publication statusPublished - May 2011

Keywords

  • Imaging
  • leukocyte trafficking / recruitment
  • cell migration
  • inflammation

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