Intravenous Thrombolysis Is Not Associated with Increased Time to Endovascular Treatment

Wouter H. Hinsenveld*, Inger R. de Ridder, Robert J. van Oostenbrugge, Wim H. van Zwam, Jan Albert Vos, Jonathan M. Coutinho, Geert J. Lycklama a Nijeholt, Jelis Boiten, Wouter J. Schonewille, MR CLEAN Registry Investigators

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background:Endovascular treatment (EVT) with or without intravenous thrombolysis (IVT) is effective and safe in is-chemic stroke caused by large vessel occlusion, but IVT might delay time to EVT or increase risk of intracranial hemorrhage (ICH). We assessed the influence of prior IVT on time to treatment and risk of ICH in patients treated with EVT.Methods:We analyzed data from the MR CLEAN Registry and included patients with an anterior circulation occlusion treated with EVT who presented directly to an intervention center, between 2014 and 2017. Primary endpoint was the door to groin time. Secondary outcomes were workflow time intervals and safety outcomes. We compared patients who received EVT only with patients who received IVT prior to EVT.Results:We included 1,427 patients directly referred to an intervention center of whom 1,023 (72%) received IVT + EVT. Adjusted door to CT imaging and door to groin time were shorter in IVT + EVT patients (difference 5.7 min [95% CI: 4.6-6.8] and 7.0 min [95% CI: 2.4-12], respectively) while CT imaging to groin time was similar between the groups. Early recanalization on digital subtraction angiography before EVT was seen more often after prior IVT (11 vs. 5.2%, aOR 2.4 [95% CI: 1.4-4.2]). Rates of symptomatic ICH were similar.Conclusion:Prior IVT did not delay door to groin times and was associated with higher rates of early recanalization, without increasing the risk of ICH. Our results do not warrant withholding IVT prior to EVT.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalCerebrovascular Diseases
Issue number3
Publication statusPublished - Jul 2020


  • Acute stroke intervention
  • Endovascular treatment of acute stroke
  • Intravenous thrombolytic therapy of stroke
  • Stroke organization
  • Workflow


Dive into the research topics of 'Intravenous Thrombolysis Is Not Associated with Increased Time to Endovascular Treatment'. Together they form a unique fingerprint.

Cite this