TY - JOUR
T1 - Intrauterine insemination
T2 - simultaneous with or 36 h after HCG? A randomized clinical trial
AU - Rijsdijk, Odette E.
AU - Cantineau, Astrid E.
AU - Bourdrez, Petra
AU - Gijsen, Tanja P.
AU - Gondrie, Ed T.
AU - Sprengers, Odette
AU - Vrouenraets, Francis P.
AU - Donners, Judith J.
AU - Evers, Johannes L.
AU - Smits, Luc J.
AU - den Hartog, Janneke E.
N1 - Funding Information:
Part of this study was presented as an oral communication at the 33rd ESHRE annual meeting in Geneva, 2017. We would like to thank all the couples who participated in our study. We would also like to thank José Keurentjes, Tine van de Laar-Asseldonk, Danith van den Nouland and Hanny Ploum for identifying and counselling eligible couples and collecting data. The study was supported by a clinical research grant from the Stichting Fertility Foundation, Maastricht. Trial registration number: Portal Toetsing Online Kenmerk NL39738.068.12.
Funding Information:
Part of this study was presented as an oral communication at the 33rd ESHRE annual meeting in Geneva, 2017. We would like to thank all the couples who participated in our study. We would also like to thank José Keurentjes, Tine van de Laar-Asseldonk, Danith van den Nouland and Hanny Ploum for identifying and counselling eligible couples and collecting data. The study was supported by a clinical research grant from the Stichting Fertility Foundation, Maastricht. Trial registration number: Portal Toetsing Online Kenmerk NL39738.068.12.
Publisher Copyright:
© 2019 Reproductive Healthcare Ltd.
PY - 2019/8
Y1 - 2019/8
N2 - Research question: Does intrauterine insemination (IUI) carried out simultaneously with HCG triggering ('simultaneous IUI') increase the ongoing pregnancy rate compared with IUI 32-36 h after HCG triggering ('regular IUI')?Study design: An open-label randomized clinical trial was conducted in seven Dutch fertility clinics. One hundred and sixty-six couples were randomized to receive simultaneous IUI and 208 couples to receive regular IUI. Treatment was allocated using a computer-based randomization algorithm using sealed opaque envelopes. Data were analysed according to the intention-to-treat principle. Couples with unexplained or mild-to-moderate male factor subfertility were eligible. Exclusion criteria were female age 42 years or older, female body mass index 35 kg/m(2) or over, double-sided tubal pathology or severe male factor subfertility. Mild ovarian stimulation was carried out by subcutaneous FSH self-administration. 'Simultaneous IUI' was carried out at the point of HCG triggering for ovulation. 'Regular IUI' was carried out 32-36 h after HCG triggering.Results: The cumulative ongoing pregnancy rate after a maximum of four cycles was 26.2% for simultaneous IUI (43 ongoing pregnancies) and 33.7% for regular IUI (70 ongoing pregnancies) (RR 0.78 95% CI 0.57 to 1.07). Ongoing pregnancy rates per cycle in the simultaneous IUI group were 6.8%, 10.5%, 9.5% and 7.4% for the first, second, third and fourth IUI cycle. In the regular IUI group, ongoing pregnancy rates were 8.3%, 16.4%, 13.5% and 9.0% for the first, second, third and fourth IUI cycle.Conclusions: This multicentre randomized controlled trial did not demonstrate that IUI carried out at the point of HCG triggering increases pregnancy rates compared with IUI carried out around the time of ovulation.
AB - Research question: Does intrauterine insemination (IUI) carried out simultaneously with HCG triggering ('simultaneous IUI') increase the ongoing pregnancy rate compared with IUI 32-36 h after HCG triggering ('regular IUI')?Study design: An open-label randomized clinical trial was conducted in seven Dutch fertility clinics. One hundred and sixty-six couples were randomized to receive simultaneous IUI and 208 couples to receive regular IUI. Treatment was allocated using a computer-based randomization algorithm using sealed opaque envelopes. Data were analysed according to the intention-to-treat principle. Couples with unexplained or mild-to-moderate male factor subfertility were eligible. Exclusion criteria were female age 42 years or older, female body mass index 35 kg/m(2) or over, double-sided tubal pathology or severe male factor subfertility. Mild ovarian stimulation was carried out by subcutaneous FSH self-administration. 'Simultaneous IUI' was carried out at the point of HCG triggering for ovulation. 'Regular IUI' was carried out 32-36 h after HCG triggering.Results: The cumulative ongoing pregnancy rate after a maximum of four cycles was 26.2% for simultaneous IUI (43 ongoing pregnancies) and 33.7% for regular IUI (70 ongoing pregnancies) (RR 0.78 95% CI 0.57 to 1.07). Ongoing pregnancy rates per cycle in the simultaneous IUI group were 6.8%, 10.5%, 9.5% and 7.4% for the first, second, third and fourth IUI cycle. In the regular IUI group, ongoing pregnancy rates were 8.3%, 16.4%, 13.5% and 9.0% for the first, second, third and fourth IUI cycle.Conclusions: This multicentre randomized controlled trial did not demonstrate that IUI carried out at the point of HCG triggering increases pregnancy rates compared with IUI carried out around the time of ovulation.
KW - HCG trigger
KW - Intrauterine insemination
KW - Mild ovarian stimulation
KW - Subfertility
KW - Timing of insemination
KW - PREGNANCY RATES
KW - COUPLES
KW - INFERTILITY
KW - FERTILITY
U2 - 10.1016/j.rbmo.2019.03.208
DO - 10.1016/j.rbmo.2019.03.208
M3 - Article
C2 - 31182355
SN - 1472-6483
VL - 39
SP - 262
EP - 268
JO - Reproductive Biomedicine Online
JF - Reproductive Biomedicine Online
IS - 2
ER -