Intrauterine environment and cognitive development in young twins

E.E. Antoniou; T. Fowler; E. Thiery; T.R. Southwood; S van Gestel; N. Jacobs; R. Vlietinck; J. van Os; F.V. Rijsdijk; C. Derom; M.P. Zeegers

doi:10.1017/S2040174413000287

Intrauterine environment and cognitive development in young twins

E.E. Antoniou^*, T. Fowler, E. Thiery, T.R. Southwood, S van Gestel, N. Jacobs, R. Vlietinck, J. van Os, F.V. Rijsdijk, C. Derom, M.P. Zeegers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children- Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (IQ). The intrauterine factors examined were birth weight, placental weight and morphology, cord knots, cord length and cord insertion. IQ scores for the varying levels of the intrauterine markers adjusting for gender and gestational age were calculated. The heritability of IQ and the association between IQ and intrauterine environment were examined. Twins with lower birth weight and cord knots had lower IQ scores. The aetiology of IQ is largely distinct from that of birth weight and cord knots, and non- shared environment may influence the observed relationships.

Original language	English
Pages (from-to)	513-521
Number of pages	9
Journal	Journal of developmental origins of health and disease
Volume	4
Issue number	6
DOIs	https://doi.org/10.1017/S2040174413000287
Publication status	Published - Dec 2013

Keywords

birth weight
intrauterine environment
IQ
twins
umbilical cord knots
LOW-BIRTH-WEIGHT
UMBILICAL-CORD
9-YEAR-OLD CHILDREN
GESTATIONAL-AGE
EARLY-CHILDHOOD
GROWTH-FACTOR
LATER LIFE
INTELLIGENCE
FETAL

Access to Document

10.1017/S2040174413000287

Cite this

@article{efb4c8be49a64213b6444b86a13d677c,

title = "Intrauterine environment and cognitive development in young twins",

abstract = "Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children- Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (IQ). The intrauterine factors examined were birth weight, placental weight and morphology, cord knots, cord length and cord insertion. IQ scores for the varying levels of the intrauterine markers adjusting for gender and gestational age were calculated. The heritability of IQ and the association between IQ and intrauterine environment were examined. Twins with lower birth weight and cord knots had lower IQ scores. The aetiology of IQ is largely distinct from that of birth weight and cord knots, and non- shared environment may influence the observed relationships.",

keywords = "birth weight, intrauterine environment, IQ, twins, umbilical cord knots, LOW-BIRTH-WEIGHT, UMBILICAL-CORD, 9-YEAR-OLD CHILDREN, GESTATIONAL-AGE, EARLY-CHILDHOOD, GROWTH-FACTOR, LATER LIFE, INTELLIGENCE, FETAL",

author = "E.E. Antoniou and T. Fowler and E. Thiery and T.R. Southwood and {van Gestel}, S and N. Jacobs and R. Vlietinck and {van Os}, J. and F.V. Rijsdijk and C. Derom and M.P. Zeegers",

year = "2013",

month = dec,

doi = "10.1017/S2040174413000287",

language = "English",

volume = "4",

pages = "513--521",

journal = "Journal of developmental origins of health and disease",

issn = "2040-1744",

publisher = "Cambridge University Press",

number = "6",

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TY - JOUR

T1 - Intrauterine environment and cognitive development in young twins

AU - Antoniou, E.E.

AU - Fowler, T.

AU - Thiery, E.

AU - Southwood, T.R.

AU - van Gestel, S

AU - Jacobs, N.

AU - Vlietinck, R.

AU - van Os, J.

AU - Rijsdijk, F.V.

AU - Derom, C.

AU - Zeegers, M.P.

PY - 2013/12

Y1 - 2013/12

N2 - Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children- Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (IQ). The intrauterine factors examined were birth weight, placental weight and morphology, cord knots, cord length and cord insertion. IQ scores for the varying levels of the intrauterine markers adjusting for gender and gestational age were calculated. The heritability of IQ and the association between IQ and intrauterine environment were examined. Twins with lower birth weight and cord knots had lower IQ scores. The aetiology of IQ is largely distinct from that of birth weight and cord knots, and non- shared environment may influence the observed relationships.

AB - Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children- Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (IQ). The intrauterine factors examined were birth weight, placental weight and morphology, cord knots, cord length and cord insertion. IQ scores for the varying levels of the intrauterine markers adjusting for gender and gestational age were calculated. The heritability of IQ and the association between IQ and intrauterine environment were examined. Twins with lower birth weight and cord knots had lower IQ scores. The aetiology of IQ is largely distinct from that of birth weight and cord knots, and non- shared environment may influence the observed relationships.

KW - birth weight

KW - intrauterine environment

KW - IQ

KW - twins

KW - umbilical cord knots

KW - LOW-BIRTH-WEIGHT

KW - UMBILICAL-CORD

KW - 9-YEAR-OLD CHILDREN

KW - GESTATIONAL-AGE

KW - EARLY-CHILDHOOD

KW - GROWTH-FACTOR

KW - LATER LIFE

KW - INTELLIGENCE

KW - FETAL

U2 - 10.1017/S2040174413000287

DO - 10.1017/S2040174413000287

M3 - Article

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SN - 2040-1744

VL - 4

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EP - 521

JO - Journal of developmental origins of health and disease

JF - Journal of developmental origins of health and disease

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