Intramyocellular lipid droplets and insulin sensitivity, the human perspective

Anne Gemmink, Bret H. Goodpaster, Patrick Schrauwen, Matthijs K. C. Hesselink*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Skeletal muscle can store excess fat as subcellular lipid droplets (LDs). While originally viewed as uninteresting static balls of triacylglycerol, it is now clear that myocellular LDs play an active role in myocellular (patho) physiology. In this review we aim to discuss the role of LDs in muscle cell insulin sensitivity and identify parameters which appear to affect this relationship. Moreover, we discuss the application of novel tools permitting detailed examination of these parameters. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

Original languageEnglish
Pages (from-to)1242-1249
Number of pages8
JournalBiochimica et Biophysica Acta-Molecular and Cell Biology of Lipids
Volume1862
Issue number10
DOIs
Publication statusPublished - Oct 2017
EventFASEB Summer Conference on Lipid Droplets: Dynamic Organelles in Metabolism and Beyond - Snowmass, Colombia
Duration: 24 Jul 201629 Jul 2016

Keywords

  • Skeletal muscle
  • Insulin resistance
  • PLIN5
  • Human
  • IMCL
  • HUMAN SKELETAL-MUSCLE
  • ADIPOSE TRIGLYCERIDE LIPASE
  • DIFFERENTIATION-RELATED PROTEIN
  • IMAGING MASS-SPECTROMETRY
  • FATTY-ACID
  • PERILIPIN 5
  • WEIGHT-LOSS
  • METABOLIC SYNDROME
  • CERAMIDE CONTENT
  • OBESE SUBJECTS

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