Intramyocellular lipid droplets and insulin sensitivity, the human perspective

Anne Gemmink; Bret H. Goodpaster; Patrick Schrauwen; Matthijs K. C. Hesselink

doi:10.1016/j.bbalip.2017.07.010

Intramyocellular lipid droplets and insulin sensitivity, the human perspective

Anne Gemmink, Bret H. Goodpaster, Patrick Schrauwen, Matthijs K. C. Hesselink^*

^*Corresponding author for this work

NUTRIM - Obesity, diabetes and cardiovascular health

Research output: Contribution to journal › Article › Academic › peer-review

207 Downloads (Pure)

Abstract

Skeletal muscle can store excess fat as subcellular lipid droplets (LDs). While originally viewed as uninteresting static balls of triacylglycerol, it is now clear that myocellular LDs play an active role in myocellular (patho) physiology. In this review we aim to discuss the role of LDs in muscle cell insulin sensitivity and identify parameters which appear to affect this relationship. Moreover, we discuss the application of novel tools permitting detailed examination of these parameters. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

Original language	English
Pages (from-to)	1242-1249
Number of pages	8
Journal	Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids
Volume	1862
Issue number	10
DOIs	https://doi.org/10.1016/j.bbalip.2017.07.010
Publication status	Published - Oct 2017
Event	FASEB Summer Conference on Lipid Droplets: Dynamic Organelles in Metabolism and Beyond - Snowmass, Colombia Duration: 24 Jul 2016 → 29 Jul 2016

Keywords

Skeletal muscle
Insulin resistance
PLIN5
Human
IMCL
HUMAN SKELETAL-MUSCLE
ADIPOSE TRIGLYCERIDE LIPASE
DIFFERENTIATION-RELATED PROTEIN
IMAGING MASS-SPECTROMETRY
FATTY-ACID
PERILIPIN 5
WEIGHT-LOSS
METABOLIC SYNDROME
CERAMIDE CONTENT
OBESE SUBJECTS

Access to Document

10.1016/j.bbalip.2017.07.010

Full TextFinal published version, 591 KBLicence: Taverne

Cite this

@article{bb2013fa15fb4409aa09d9534fb84cac,

title = "Intramyocellular lipid droplets and insulin sensitivity, the human perspective",

abstract = "Skeletal muscle can store excess fat as subcellular lipid droplets (LDs). While originally viewed as uninteresting static balls of triacylglycerol, it is now clear that myocellular LDs play an active role in myocellular (patho) physiology. In this review we aim to discuss the role of LDs in muscle cell insulin sensitivity and identify parameters which appear to affect this relationship. Moreover, we discuss the application of novel tools permitting detailed examination of these parameters. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.",

keywords = "Skeletal muscle, Insulin resistance, PLIN5, Human, IMCL, HUMAN SKELETAL-MUSCLE, ADIPOSE TRIGLYCERIDE LIPASE, DIFFERENTIATION-RELATED PROTEIN, IMAGING MASS-SPECTROMETRY, FATTY-ACID, PERILIPIN 5, WEIGHT-LOSS, METABOLIC SYNDROME, CERAMIDE CONTENT, OBESE SUBJECTS",

author = "Anne Gemmink and Goodpaster, {Bret H.} and Patrick Schrauwen and Hesselink, {Matthijs K. C.}",

year = "2017",

month = oct,

doi = "10.1016/j.bbalip.2017.07.010",

language = "English",

volume = "1862",

pages = "1242--1249",

journal = "Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids",

issn = "1388-1981",

publisher = "Elsevier",

number = "10",

note = "FASEB Summer Conference on Lipid Droplets : Dynamic Organelles in Metabolism and Beyond ; Conference date: 24-07-2016 Through 29-07-2016",

}

TY - JOUR

T1 - Intramyocellular lipid droplets and insulin sensitivity, the human perspective

AU - Gemmink, Anne

AU - Goodpaster, Bret H.

AU - Schrauwen, Patrick

AU - Hesselink, Matthijs K. C.

PY - 2017/10

Y1 - 2017/10

N2 - Skeletal muscle can store excess fat as subcellular lipid droplets (LDs). While originally viewed as uninteresting static balls of triacylglycerol, it is now clear that myocellular LDs play an active role in myocellular (patho) physiology. In this review we aim to discuss the role of LDs in muscle cell insulin sensitivity and identify parameters which appear to affect this relationship. Moreover, we discuss the application of novel tools permitting detailed examination of these parameters. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

AB - Skeletal muscle can store excess fat as subcellular lipid droplets (LDs). While originally viewed as uninteresting static balls of triacylglycerol, it is now clear that myocellular LDs play an active role in myocellular (patho) physiology. In this review we aim to discuss the role of LDs in muscle cell insulin sensitivity and identify parameters which appear to affect this relationship. Moreover, we discuss the application of novel tools permitting detailed examination of these parameters. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

KW - Skeletal muscle

KW - Insulin resistance

KW - PLIN5

KW - Human

KW - IMCL

KW - HUMAN SKELETAL-MUSCLE

KW - ADIPOSE TRIGLYCERIDE LIPASE

KW - DIFFERENTIATION-RELATED PROTEIN

KW - IMAGING MASS-SPECTROMETRY

KW - FATTY-ACID

KW - PERILIPIN 5

KW - WEIGHT-LOSS

KW - METABOLIC SYNDROME

KW - CERAMIDE CONTENT

KW - OBESE SUBJECTS

U2 - 10.1016/j.bbalip.2017.07.010

DO - 10.1016/j.bbalip.2017.07.010

M3 - Article

C2 - 28739280

SN - 1388-1981

VL - 1862

SP - 1242

EP - 1249

JO - Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids

IS - 10

T2 - FASEB Summer Conference on Lipid Droplets

Y2 - 24 July 2016 through 29 July 2016

ER -