Intracerebroventricular Administration of a 2 '-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain

Lodewijk J. A. Toonen; Joao Casaca-Carreira; Maria Pellise-Tintore; Hailiang Mei; Yasin Temel; Ali Jahanshahi; Willeke M. C. van Roon-Mom

doi:10.1089/nat.2017.0705

Intracerebroventricular Administration of a 2 '-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain

Lodewijk J. A. Toonen, Joao Casaca-Carreira, Maria Pellise-Tintore, Hailiang Mei, Yasin Temel, Ali Jahanshahi, Willeke M. C. van Roon-Mom

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	63-73
Number of pages	11
Journal	Nucleic Acid Therapeutics
Volume	28
Issue number	2
DOIs	https://doi.org/10.1089/nat.2017.0705
Publication status	Published - 1 Apr 2018

Keywords

immune stimulation
antisense oligonucleotide
2 '-O-methyl
mouse brain
CENTRAL-NERVOUS-SYSTEM
DIFFERENTIAL EXPRESSION ANALYSIS
TOLL-LIKE RECEPTORS
2',5'-OLIGOADENYLATE SYNTHETASE
COMPLEMENT ACTIVATION
HUNTINGTONS-DISEASE
NONHUMAN-PRIMATES
STRANDED RNA
IN-VIVO
OLIGODEOXYNUCLEOTIDES

Cite this

Toonen, L. J. A., Casaca-Carreira, J., Pellise-Tintore, M., Mei, H., Temel, Y., Jahanshahi, A., & van Roon-Mom, W. M. C. (2018). Intracerebroventricular Administration of a 2 '-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain. Nucleic Acid Therapeutics, 28(2), 63-73. https://doi.org/10.1089/nat.2017.0705

Toonen, Lodewijk J. A. ; Casaca-Carreira, Joao ; Pellise-Tintore, Maria ; Mei, Hailiang ; Temel, Yasin ; Jahanshahi, Ali ; van Roon-Mom, Willeke M. C. / Intracerebroventricular Administration of a 2 '-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain. In: Nucleic Acid Therapeutics. 2018 ; Vol. 28, No. 2. pp. 63-73.

@article{edf03d5733804a4ca8ab7efdda4be63b,

title = "Intracerebroventricular Administration of a 2 '-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain",

keywords = "immune stimulation, antisense oligonucleotide, 2 '-O-methyl, mouse brain, CENTRAL-NERVOUS-SYSTEM, DIFFERENTIAL EXPRESSION ANALYSIS, TOLL-LIKE RECEPTORS, 2',5'-OLIGOADENYLATE SYNTHETASE, COMPLEMENT ACTIVATION, HUNTINGTONS-DISEASE, NONHUMAN-PRIMATES, STRANDED RNA, IN-VIVO, OLIGODEOXYNUCLEOTIDES",

author = "Toonen, {Lodewijk J. A.} and Joao Casaca-Carreira and Maria Pellise-Tintore and Hailiang Mei and Yasin Temel and Ali Jahanshahi and {van Roon-Mom}, {Willeke M. C.}",

year = "2018",

month = apr

day = "1",

doi = "10.1089/nat.2017.0705",

language = "English",

volume = "28",

pages = "63--73",

journal = "Nucleic Acid Therapeutics",

issn = "2159-3337",

publisher = "Mary Ann Liebert Inc.",

number = "2",

}

Toonen, LJA, Casaca-Carreira, J, Pellise-Tintore, M, Mei, H, Temel, Y, Jahanshahi, A & van Roon-Mom, WMC 2018, 'Intracerebroventricular Administration of a 2 '-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain', Nucleic Acid Therapeutics, vol. 28, no. 2, pp. 63-73. https://doi.org/10.1089/nat.2017.0705

Intracerebroventricular Administration of a 2 '-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain. / Toonen, Lodewijk J. A.; Casaca-Carreira, Joao; Pellise-Tintore, Maria; Mei, Hailiang; Temel, Yasin; Jahanshahi, Ali; van Roon-Mom, Willeke M. C.

In: Nucleic Acid Therapeutics, Vol. 28, No. 2, 01.04.2018, p. 63-73.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Intracerebroventricular Administration of a 2 '-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain

AU - Toonen, Lodewijk J. A.

AU - Casaca-Carreira, Joao

AU - Pellise-Tintore, Maria

AU - Mei, Hailiang

AU - Temel, Yasin

AU - Jahanshahi, Ali

AU - van Roon-Mom, Willeke M. C.

PY - 2018/4/1

Y1 - 2018/4/1

KW - immune stimulation

KW - antisense oligonucleotide

KW - 2 '-O-methyl

KW - mouse brain

KW - CENTRAL-NERVOUS-SYSTEM

KW - DIFFERENTIAL EXPRESSION ANALYSIS

KW - TOLL-LIKE RECEPTORS

KW - 2',5'-OLIGOADENYLATE SYNTHETASE

KW - COMPLEMENT ACTIVATION

KW - HUNTINGTONS-DISEASE

KW - NONHUMAN-PRIMATES

KW - STRANDED RNA

KW - IN-VIVO

KW - OLIGODEOXYNUCLEOTIDES

U2 - 10.1089/nat.2017.0705

DO - 10.1089/nat.2017.0705

M3 - Article

VL - 28

SP - 63

EP - 73

JO - Nucleic Acid Therapeutics

JF - Nucleic Acid Therapeutics

SN - 2159-3337

IS - 2

ER -

Access to Document

10.1089/nat.2017.0705

https://www.liebertpub.com/doi/pdf/10.1089/nat.2017.0705