Intracerebroventricular Administration of a 2 '-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain

Lodewijk J. A. Toonen, Joao Casaca-Carreira, Maria Pellise-Tintore, Hailiang Mei, Yasin Temel, Ali Jahanshahi, Willeke M. C. van Roon-Mom

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)63-73
Number of pages11
JournalNucleic Acid Therapeutics
Volume28
Issue number2
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • immune stimulation
  • antisense oligonucleotide
  • 2 '-O-methyl
  • mouse brain
  • CENTRAL-NERVOUS-SYSTEM
  • DIFFERENTIAL EXPRESSION ANALYSIS
  • TOLL-LIKE RECEPTORS
  • 2',5'-OLIGOADENYLATE SYNTHETASE
  • COMPLEMENT ACTIVATION
  • HUNTINGTONS-DISEASE
  • NONHUMAN-PRIMATES
  • STRANDED RNA
  • IN-VIVO
  • OLIGODEOXYNUCLEOTIDES

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