Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment

Ann Hoeben*, Linda van de Winkel, Frank Hoebers, Kenneth Kross, Chantal Driessen, Pieter Slootweg, Vivianne C. G. Tjan-Heijnen, Carla van Herpen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background. Sinonasal intestinal-type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized.
Methods. Articles on ITAC histopathology, molecular profile, and current
treatment options of this specific tumor were identified and reviewed,
using the electronic databases Pubmed, Medline, Cochrane, and Web of Science. 
Results. This article reviews what is currently known on the histopathology, tumorigenesis, molecular characteristics, and standardized treatment options of ITAC.Conclusion. More translational research is needed to identify druggabletargets that may lead to a personalized treatment plan in order toimprove long-term outcome in patients with locally advanced and/or metastasized ITAC
Original languageEnglish
Pages (from-to)1564-1570
Number of pages7
JournalHead and Neck-Journal for the Sciences and Specialties of the Head and Neck
Publication statusPublished - Oct 2016


  • intestinal-type adenocarcinoma
  • sinonasal adenocarcinoma
  • treatment
  • gene expression
  • pathology


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