Intestinal multicellular organoids to study colorectal cancer

M. Idris, M.M. Alves, R.M.W. Hofstra, M.M. Mahe, V. Melotte*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

4 Citations (Web of Science)

Abstract

Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. In this review, we describe both normal and CRC intestinal organoid models and their utility in the cancer research field. Besides highlighting studies that develop epithelial CRC organoid models, i.e. organoids without tumor microenvironment (TME) cellular components, we emphasize on the need for TME in CRC modeling, to help reduce translational disparities in this area. Also, we discuss the utilization of CRC organoids derived from pluripotent stem cells, as well as their potential to be used in cancer research. Finally, limitations and challenges in the current CRC organoids field, are discussed.
Original languageEnglish
Article number188586
Number of pages9
JournalBiochimica et Biophysica Acta-reviews on Cancer
Volume1876
Issue number2
DOIs
Publication statusPublished - 1 Dec 2021

Keywords

  • Colorectal cancer
  • Organoids
  • Tumor microenvironment
  • Modeling
  • PLURIPOTENT STEM-CELLS
  • HUMAN COLON
  • MICROENVIRONMENT
  • DIFFERENTIATION
  • EPITHELIUM
  • DIVERSITY
  • PLATFORM
  • DISEASE

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