TY - JOUR
T1 - Interplay Between Childhood Maltreatment, Subclinical Post-Traumatic Stress Symptoms, and IQ
T2 - Findings From the EU-GEI Multicentre Case–Control Study
AU - Sideli, Lucia
AU - Aas, Monica
AU - Alameda, Luis
AU - Trotta, Giulia
AU - La Barbera, Daniele
AU - La Cascia, Caterina
AU - Ferraro, Laura
AU - Velthorst, Eva
AU - Tripoli, Giada
AU - Schimmenti, Adriano
AU - Fontana, Andrea
AU - Quattrone, Diego
AU - Gayer-Anderson, Charlotte
AU - Rodriguez, Victoria
AU - Spinazzola, Edoardo
AU - Stilo, Simona
AU - Seminerio, Fabio
AU - Sartorio, Crocettarachele
AU - Marrazzo, Giovanna
AU - Lasalvia, Antonio
AU - Tosato, Sarah
AU - Tarricone, Ilaria
AU - D'Andrea, Giuseppe
AU - Amoretti, Silvia
AU - Andreu-Bernabeu, Álvaro
AU - Baudin, Grégoire
AU - Beards, Stephanie
AU - Bonetto, Chiara
AU - Bonora, Elena
AU - Cabrera, Bibiana
AU - Carracedo, Angel
AU - Charpeaud, Thomas
AU - Costas, Javier
AU - Cristofalo, Doriana
AU - Durán-Cutilla, Manuel
AU - Ferchiou, Aziz
AU - Fraguas, David
AU - Franke, Nathalie
AU - Frijda, Flora
AU - Llorente, Cloe
AU - Garcia-Portilla, Paz
AU - González Peñas, Javier
AU - Hubbard, Kathryn
AU - Jamain, Stéphane
AU - Jiménez-López, Estela
AU - Leboyer, Marion
AU - López Montoya, Gonzalo
AU - Selten, Jean Paul
AU - Van Os, Jim
AU - Rutten, Bart P.
AU - EU-GEI WP2 Group
N1 - Funding Information:
The EU\u2010GEI Study is funded by the European Community's Seventh Framework Programme [HEALTH\u2010F2\u20102010\u2010241909] (Project EU\u2010GEI) and the S\u00E3o Paulo Research Foundation [2012/0417\u20100]. Monica Aas is supported by a Medical Research Council (MRC) fellowship [MR/W027720/1]. Luis Alameda was supported by fellowships from Fondation Adrian et Simone Frutiger and Carigest SA. Celso Arango has received support from the Spanish Ministry of Science, Innovation and Universities, Instituto de Salud Carlos III (ISCIII), co\u2010financed by the European Union, European Regional Development Funds from the European Commission, \u2018A way of making Europe\u2019, financed by the European Union NextGenerationEU [PMP21/00051, PI19/01024, PI22/01824], CIBERSAM, Government of the Community of Madrid [B2017/BMD\u20103740, AGES\u2010CM\u20102], European Union Structural Funds, European Union Seventh Framework Programme, European Union H2020 Programme under the Innovative Medicines Initiative 2 Joint Undertaking: Project PRISM\u20102 [101034377], Project AIMS\u20102\u2010TRIALS [777394], Horizon Europe, the National Institute of Mental Health [1U01MH124639\u201001 ProNET, 5P50MH115846\u201003 FEP\u2010CAUSAL], Fundaci\u00F3n Familia Alonso and Fundaci\u00F3n Alicia Koplowitz. Helen L. Fisher, Charlotte Gayer\u2010Anderson and Craig Morgan are supported by the Economic and Social Research Council (ESRC) Centre for Society and Mental Health at King's College London [ES/S012567/1]. Diego Quattrone is supported by the MRC Clinical Academic Research Partnership [MR/W030608/1]. Edoardo Spinazzola was supported by Lord Leverhulme's Charitable Trust and the Velvet Foundation and by the MRC [MR/T007818/1]. Bart P. Rutten is funded by a VIDI award from the Dutch Research Council [91.718.336]. The views expressed are those of the authors and not necessarily those of the ESRC or King's College London. Funding:
Funding Information:
Funding: The EU-GEI Study is funded by the European Community's Seventh Framework Programme [HEALTH-F2-2010-241909] (Project EU-GEI) and the S\u00E3o Paulo Research Foundation [2012/0417-0]. Monica Aas is supported by a Medical Research Council (MRC) fellowship [MR/W027720/1]. Luis Alameda was supported by fellowships from Fondation Adrian et Simone Frutiger and Carigest SA. Celso Arango has received support from the Spanish Ministry of Science, Innovation and Universities, Instituto de Salud Carlos III (ISCIII), co-financed by the European Union, European Regional Development Funds from the European Commission, \u2018A way of making Europe\u2019, financed by the European Union NextGenerationEU [PMP21/00051, PI19/01024, PI22/01824], CIBERSAM, Government of the Community of Madrid\u00A0[B2017/BMD-3740, AGES-CM-2], European Union Structural Funds, European Union Seventh Framework Programme, European Union H2020 Programme under the Innovative Medicines Initiative 2 Joint Undertaking: Project PRISM-2 [101034377], Project AIMS-2-TRIALS [777394], Horizon Europe, the National Institute of Mental Health [1U01MH124639-01 ProNET, 5P50MH115846-03 FEP-CAUSAL], Fundaci\u00F3n Familia Alonso and Fundaci\u00F3n Alicia Koplowitz. Helen L. Fisher, Charlotte Gayer-Anderson and Craig Morgan are supported by the Economic and Social Research Council (ESRC) Centre for Society and Mental Health at King's College London [ES/S012567/1]. Diego Quattrone is supported by the MRC Clinical Academic Research Partnership [MR/W030608/1]. Edoardo Spinazzola was supported by Lord Leverhulme's Charitable Trust and the Velvet Foundation and by the MRC [MR/T007818/1]. Bart P. Rutten is funded by a VIDI award from the Dutch Research Council [91.718.336]. The views expressed are those of the authors and not necessarily those of the ESRC or King's College London. We are grateful to the EU-GEI study participants for their essential contribution to this project. Open access publishing facilitated by Libera Universita Maria Santissima Assunta, as part of the Wiley - CRUI-CARE agreement.
Publisher Copyright:
© 2025 The Author(s). Early Intervention in Psychiatry published by John Wiley & Sons Australia, Ltd.
PY - 2025/8/1
Y1 - 2025/8/1
N2 - Introduction: Evidence suggests that childhood maltreatment affects cognitive performance in both patients with psychosis and community controls. However, the interplay between childhood maltreatment, post-traumatic stress symptoms (PTSS), and intelligence has not been investigated. This study investigated the relationship between childhood maltreatment, subclinical PTSS, and intelligence among patients with first-episode psychosis (FEP) and community controls. Methods: Patients with FEP (N = 602) and controls (N = 853) from the EU-GEI study were assessed for childhood maltreatment, PTSS, and intelligence quotient (IQ). Results: PTSS were associated with lower IQ among community controls but not among patients with FEP. In the FEP group, an interaction (p = 0.044) between PTSS and childhood maltreatment on IQ was found, such that the association between PTSS and lower IQ was only present among those exposed to childhood maltreatment. No interaction was evident in controls (p = 0.826). Conclusions: The findings suggest the relevance of cognitive rehabilitation for FEP patients with childhood maltreatment and PTSS.
AB - Introduction: Evidence suggests that childhood maltreatment affects cognitive performance in both patients with psychosis and community controls. However, the interplay between childhood maltreatment, post-traumatic stress symptoms (PTSS), and intelligence has not been investigated. This study investigated the relationship between childhood maltreatment, subclinical PTSS, and intelligence among patients with first-episode psychosis (FEP) and community controls. Methods: Patients with FEP (N = 602) and controls (N = 853) from the EU-GEI study were assessed for childhood maltreatment, PTSS, and intelligence quotient (IQ). Results: PTSS were associated with lower IQ among community controls but not among patients with FEP. In the FEP group, an interaction (p = 0.044) between PTSS and childhood maltreatment on IQ was found, such that the association between PTSS and lower IQ was only present among those exposed to childhood maltreatment. No interaction was evident in controls (p = 0.826). Conclusions: The findings suggest the relevance of cognitive rehabilitation for FEP patients with childhood maltreatment and PTSS.
KW - childhood maltreatment
KW - first episode
KW - intelligence
KW - post-traumatic stress
KW - psychosis
U2 - 10.1111/eip.70079
DO - 10.1111/eip.70079
M3 - Article
SN - 1751-7885
VL - 19
JO - Early Intervention in Psychiatry
JF - Early Intervention in Psychiatry
IS - 8
M1 - e70079
ER -