Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer

Robert M. Kwee; Alexander K. Dik; Meindert N. Sosef; Ralph C. M. Berendsen; Sander Sassen; Guido Lammering; Ruud Clarijs; Liekele E. Oostenbrug; Rachel L. G. M. Blom; Roy F. A. Vliegen

doi:10.1371/journal.pone.0092211

Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer

Robert M. Kwee^*, Alexander K. Dik, Meindert N. Sosef, Ralph C. M. Berendsen, Sander Sassen, Guido Lammering, Ruud Clarijs, Liekele E. Oostenbrug, Rachel L. G. M. Blom, Roy F. A. Vliegen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer. Methods: Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reproducibility of apparent diffusion coefficient (ADC) measurements by manual (freehand) and semi-automated volumetric methods was assessed. Results: Interobserver reproducibility for the assessment of mean tumor ADC by the manual measurement method was good, with an ICC of 0.69 (95% CI, 0.36 to 0.85; P = 0.001). Interobserver reproducibility for the assessment of mean tumor ADC by the semi-automated volumetric measurement method was very good, with an ICC of 0.96 (95% CI, 0.91 to 0.98; P, 0.001). Conclusion: Semi-automated volumetric ADC measurements have higher reproducibility than manual ADC measurements in assessing tumor response to chemoradiotherapy in patients with esophageal adenocarcinoma.

Original language	English
Article number	e92211
Journal	PLOS ONE
Volume	9
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0092211
Publication status	Published - 4 Apr 2014

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10.1371/journal.pone.0092211Licence: CC BY

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Kwee, R. M., Dik, A. K., Sosef, M. N., Berendsen, R. C. M., Sassen, S., Lammering, G., Clarijs, R., Oostenbrug, L. E., Blom, R. L. G. M., & Vliegen, R. F. A. (2014). Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer. PLOS ONE, 9(4), Article e92211. https://doi.org/10.1371/journal.pone.0092211

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title = "Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer",

abstract = "Objective: To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer. Methods: Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reproducibility of apparent diffusion coefficient (ADC) measurements by manual (freehand) and semi-automated volumetric methods was assessed. Results: Interobserver reproducibility for the assessment of mean tumor ADC by the manual measurement method was good, with an ICC of 0.69 (95\% CI, 0.36 to 0.85; P = 0.001). Interobserver reproducibility for the assessment of mean tumor ADC by the semi-automated volumetric measurement method was very good, with an ICC of 0.96 (95\% CI, 0.91 to 0.98; P, 0.001). Conclusion: Semi-automated volumetric ADC measurements have higher reproducibility than manual ADC measurements in assessing tumor response to chemoradiotherapy in patients with esophageal adenocarcinoma.",

author = "Kwee, \{Robert M.\} and Dik, \{Alexander K.\} and Sosef, \{Meindert N.\} and Berendsen, \{Ralph C. M.\} and Sander Sassen and Guido Lammering and Ruud Clarijs and Oostenbrug, \{Liekele E.\} and Blom, \{Rachel L. G. M.\} and Vliegen, \{Roy F. A.\}",

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doi = "10.1371/journal.pone.0092211",

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T1 - Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer

AU - Kwee, Robert M.

AU - Dik, Alexander K.

AU - Sosef, Meindert N.

AU - Berendsen, Ralph C. M.

AU - Sassen, Sander

AU - Lammering, Guido

AU - Clarijs, Ruud

AU - Oostenbrug, Liekele E.

AU - Blom, Rachel L. G. M.

AU - Vliegen, Roy F. A.

PY - 2014/4/4

Y1 - 2014/4/4

N2 - Objective: To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer. Methods: Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reproducibility of apparent diffusion coefficient (ADC) measurements by manual (freehand) and semi-automated volumetric methods was assessed. Results: Interobserver reproducibility for the assessment of mean tumor ADC by the manual measurement method was good, with an ICC of 0.69 (95% CI, 0.36 to 0.85; P = 0.001). Interobserver reproducibility for the assessment of mean tumor ADC by the semi-automated volumetric measurement method was very good, with an ICC of 0.96 (95% CI, 0.91 to 0.98; P, 0.001). Conclusion: Semi-automated volumetric ADC measurements have higher reproducibility than manual ADC measurements in assessing tumor response to chemoradiotherapy in patients with esophageal adenocarcinoma.

AB - Objective: To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer. Methods: Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reproducibility of apparent diffusion coefficient (ADC) measurements by manual (freehand) and semi-automated volumetric methods was assessed. Results: Interobserver reproducibility for the assessment of mean tumor ADC by the manual measurement method was good, with an ICC of 0.69 (95% CI, 0.36 to 0.85; P = 0.001). Interobserver reproducibility for the assessment of mean tumor ADC by the semi-automated volumetric measurement method was very good, with an ICC of 0.96 (95% CI, 0.91 to 0.98; P, 0.001). Conclusion: Semi-automated volumetric ADC measurements have higher reproducibility than manual ADC measurements in assessing tumor response to chemoradiotherapy in patients with esophageal adenocarcinoma.

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DO - 10.1371/journal.pone.0092211

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JO - PLOS ONE

JF - PLOS ONE

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M1 - e92211

ER -

Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer

Abstract

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