Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer

Robert M. Kwee*, Alexander K. Dik, Meindert N. Sosef, Ralph C. M. Berendsen, Sander Sassen, Guido Lammering, Ruud Clarijs, Liekele E. Oostenbrug, Rachel L. G. M. Blom, Roy F. A. Vliegen

*Corresponding author for this work

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27 Citations (Web of Science)

Abstract

Objective: To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer. Methods: Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reproducibility of apparent diffusion coefficient (ADC) measurements by manual (freehand) and semi-automated volumetric methods was assessed. Results: Interobserver reproducibility for the assessment of mean tumor ADC by the manual measurement method was good, with an ICC of 0.69 (95% CI, 0.36 to 0.85; P = 0.001). Interobserver reproducibility for the assessment of mean tumor ADC by the semi-automated volumetric measurement method was very good, with an ICC of 0.96 (95% CI, 0.91 to 0.98; P, 0.001). Conclusion: Semi-automated volumetric ADC measurements have higher reproducibility than manual ADC measurements in assessing tumor response to chemoradiotherapy in patients with esophageal adenocarcinoma.
Original languageEnglish
Article numbere92211
JournalPLOS ONE
Volume9
Issue number4
DOIs
Publication statusPublished - 4 Apr 2014

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