International Patterns of Practice in the Management of Radiation Therapy-induced Nausea and Vomiting

Kristopher Dennis, Liying Zhang, Stephen Lutz, Angela van Baardwijk, Yvette van der Linden, Tanya Holt, Palmira Foro Arnalot, Jean-Leon Lagrange, Ernesto Maranzano, Rico Liu, Kam-Hung Wong, Lea-Choung Wong, Vassilios Vassiliou, Benjamin W. Corn, Carlo De Angelis, Lori Holden, C. Shun Wong, Edward Chow*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Purpose: To investigate international patterns of practice in the management of radiation therapy-induced nausea and vomiting (RINV). Methods and Materials: Oncologists prescribing radiation therapy in the United States, Canada, The Netherlands, Australia, New Zealand, Spain, Italy, France, Hong Kong, Singapore, Cyprus, and Israel completed a Web-based survey that was based on 6 radiation therapy-only clinical cases modeled after the minimal-, low-, moderate-, and high-emetic risk levels defined in the antiemetic guidelines of the American Society of Clinical Oncology and the Multinational Association of Supportive Care in Cancer. For each case, respondents estimated the risks of nausea and vomiting separately and committed to an initial management approach. Results: In total, 1022 responses were received. Risk estimates and management decisions for the minimal-and high-risk cases varied little and were in line with guideline standards, whereas those for the low-and moderate-risk cases varied greatly. The most common initial management strategies were as follows: rescue therapy for a minimal-risk case (63% of respondents), 2 low-risk cases (56% and 80%), and 1 moderate-risk case (66%); and prophylactic therapy for a second moderate-risk case (75%) and a high-risk case (95%). The serotonin (5-HT) 3 receptor antagonists were the most commonly recommended prophylactic agents. On multivariate analysis, factors predictive of a decision for prophylactic or rescue therapy were risk estimates of nausea and vomiting, awareness of the American Society of Clinical Oncology antiemetic guideline, and European Society for Therapeutic Radiology and Oncology membership. Conclusions: Risk estimates and management strategies for RINV varied, especially for low-and moderate-risk radiation therapy cases. Radiation therapy-induced nausea and vomiting are under-studied treatment sequelae. New observational and translational studies are needed to allow for individual patient risk assessment and to refine antiemetic guideline management recommendations.
Original languageEnglish
Pages (from-to)E49-E60
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number1
Publication statusPublished - 1 Sept 2012


Dive into the research topics of 'International Patterns of Practice in the Management of Radiation Therapy-induced Nausea and Vomiting'. Together they form a unique fingerprint.

Cite this