Intermittent pacing therapy favorably modulates infarct remodeling

Andre Uitterdijk, Tirza Springeling, Kevin C. M. Hermans, Daphne Merkus, Vincent J. de Beer, Charlotte Gorsse-Bakker, Eric Mokelke, Evangelos P. Daskalopoulos, Piotr A. Wielopolski, Jack P. M. Cleutjens, W. Matthijs Blankesteijn, Frits W. Prinzen, Willem J. van der Giessen, Robert-Jan M. van Geuns, Dirk J. Duncker*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

Despite early revascularization, remodeling and dysfunction of the left ventricle (LV) after acute myocardial infarction (AMI) remain important therapeutic targets. Intermittent pacing therapy (IPT) of the LV can limit infarct size, when applied during early reperfusion. However, the effects of IPT on post-AMI LV remodeling and infarct healing are unknown. We therefore investigated the effects of IPT on global LV remodeling and infarct geometry in swine with a 3-day old AMI. For this purpose, fifteen pigs underwent 2 h ligation of the left circumflex coronary artery followed by reperfusion. An epicardial pacing lead was implanted in the peri-infarct zone. After three days, global LV remodeling and infarct geometry were assessed using magnetic resonance imaging (MRI). Animals were stratified into MI control and IPT groups. Thirty-five days post-AMI, follow-up MRI was obtained and myofibroblast content, markers of extracellular matrix (ECM) turnover and Wnt/frizzled signaling in infarct and non-infarct control tissue were studied. Results showed that IPT had no significant effect on global LV remodeling, function or infarct mass, but modulated infarct healing. In MI control pigs, infarct mass reduction was principally due to a 26.2 +/- 4.4% reduction in infarct thickness (P

Original languageEnglish
Article number28
Number of pages10
JournalBasic Research in Cardiology
Volume112
Issue number3
DOIs
Publication statusPublished - May 2017

Keywords

  • Myocardial infarction
  • Myofibroblasts
  • Infarct geometry
  • Infarct expansion
  • Infarct healing
  • Swine
  • PRECONDITIONS RABBIT MYOCARDIUM
  • CORONARY-ARTERY-DISEASE
  • HEART-FAILURE
  • CARDIAC FIBROBLASTS
  • REPERFUSION INJURY
  • EXPANSION
  • SIZE
  • TARGET
  • TISSUE
  • SWINE

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