TY - JOUR
T1 - Intermittent pacing therapy favorably modulates infarct remodeling
AU - Uitterdijk, Andre
AU - Springeling, Tirza
AU - Hermans, Kevin C. M.
AU - Merkus, Daphne
AU - de Beer, Vincent J.
AU - Gorsse-Bakker, Charlotte
AU - Mokelke, Eric
AU - Daskalopoulos, Evangelos P.
AU - Wielopolski, Piotr A.
AU - Cleutjens, Jack P. M.
AU - Blankesteijn, W. Matthijs
AU - Prinzen, Frits W.
AU - van der Giessen, Willem J.
AU - van Geuns, Robert-Jan M.
AU - Duncker, Dirk J.
PY - 2017/5
Y1 - 2017/5
N2 - Despite early revascularization, remodeling and dysfunction of the left ventricle (LV) after acute myocardial infarction (AMI) remain important therapeutic targets. Intermittent pacing therapy (IPT) of the LV can limit infarct size, when applied during early reperfusion. However, the effects of IPT on post-AMI LV remodeling and infarct healing are unknown. We therefore investigated the effects of IPT on global LV remodeling and infarct geometry in swine with a 3-day old AMI. For this purpose, fifteen pigs underwent 2 h ligation of the left circumflex coronary artery followed by reperfusion. An epicardial pacing lead was implanted in the peri-infarct zone. After three days, global LV remodeling and infarct geometry were assessed using magnetic resonance imaging (MRI). Animals were stratified into MI control and IPT groups. Thirty-five days post-AMI, follow-up MRI was obtained and myofibroblast content, markers of extracellular matrix (ECM) turnover and Wnt/frizzled signaling in infarct and non-infarct control tissue were studied. Results showed that IPT had no significant effect on global LV remodeling, function or infarct mass, but modulated infarct healing. In MI control pigs, infarct mass reduction was principally due to a 26.2 +/- 4.4% reduction in infarct thickness (P
AB - Despite early revascularization, remodeling and dysfunction of the left ventricle (LV) after acute myocardial infarction (AMI) remain important therapeutic targets. Intermittent pacing therapy (IPT) of the LV can limit infarct size, when applied during early reperfusion. However, the effects of IPT on post-AMI LV remodeling and infarct healing are unknown. We therefore investigated the effects of IPT on global LV remodeling and infarct geometry in swine with a 3-day old AMI. For this purpose, fifteen pigs underwent 2 h ligation of the left circumflex coronary artery followed by reperfusion. An epicardial pacing lead was implanted in the peri-infarct zone. After three days, global LV remodeling and infarct geometry were assessed using magnetic resonance imaging (MRI). Animals were stratified into MI control and IPT groups. Thirty-five days post-AMI, follow-up MRI was obtained and myofibroblast content, markers of extracellular matrix (ECM) turnover and Wnt/frizzled signaling in infarct and non-infarct control tissue were studied. Results showed that IPT had no significant effect on global LV remodeling, function or infarct mass, but modulated infarct healing. In MI control pigs, infarct mass reduction was principally due to a 26.2 +/- 4.4% reduction in infarct thickness (P
KW - Myocardial infarction
KW - Myofibroblasts
KW - Infarct geometry
KW - Infarct expansion
KW - Infarct healing
KW - Swine
KW - PRECONDITIONS RABBIT MYOCARDIUM
KW - CORONARY-ARTERY-DISEASE
KW - HEART-FAILURE
KW - CARDIAC FIBROBLASTS
KW - REPERFUSION INJURY
KW - EXPANSION
KW - SIZE
KW - TARGET
KW - TISSUE
KW - SWINE
U2 - 10.1007/s00395-017-0616-3
DO - 10.1007/s00395-017-0616-3
M3 - Article
C2 - 28386775
SN - 0300-8428
VL - 112
JO - Basic Research in Cardiology
JF - Basic Research in Cardiology
IS - 3
M1 - 28
ER -