Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer

Alexander C. Dowell; Ellen Cobby; Kaisheng Wen; Adam J. Devall; Vinnie During; Jane Anderson; Nicholas D. James; Kar K. Cheng; Maurice P. Zeegers; Richard T. Bryan; Graham S. Taylor

doi:10.1371/journal.pone.0184841

Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer

Alexander C. Dowell, Ellen Cobby, Kaisheng Wen, Adam J. Devall, Vinnie During, Jane Anderson, Nicholas D. James, Kar K. Cheng, Maurice P. Zeegers, Richard T. Bryan^*, Graham S. Taylor

^*Corresponding author for this work

CAPHRI - Optimising Patient Care

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The tumour immune microenvironment is considered to influence cancer behaviour and outcome. Using a panel of markers for innate and adaptive immune cells we set out to characterise and understand the bladder tumour microenvironment of 114 patients from a prospective multicentre cohort of newly-diagnosed bladder cancer patients, followed-up for 4.33 +/- 1.71 years. We found IL-17-positive cells were significantly increased in primary and concomitant carcinoma in situ (CIS), p

Original language	English
Article number	0184841
Number of pages	17
Journal	PLOS ONE
Volume	12
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0184841
Publication status	Published - 20 Sept 2017

Keywords

BACILLUS-CALMETTE-GUERIN
CARCINOMA IN-SITU
COLORECTAL-CANCER
IL-17
PROGRESSION
RECURRENCE
EXPRESSION
CYTOKINES
INFLAMMATION
PSORIASIS

Access to Document

10.1371/journal.pone.0184841Licence: CC BY

Cite this

Dowell, A. C., Cobby, E., Wen, K., Devall, A. J., During, V., Anderson, J., James, N. D., Cheng, K. K., Zeegers, M. P., Bryan, R. T., & Taylor, G. S. (2017). Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer. PLOS ONE, 12(9), Article 0184841. https://doi.org/10.1371/journal.pone.0184841

@article{2ec1ebb16cf34731bf7f8dadeac8fcad,

title = "Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer",

abstract = "The tumour immune microenvironment is considered to influence cancer behaviour and outcome. Using a panel of markers for innate and adaptive immune cells we set out to characterise and understand the bladder tumour microenvironment of 114 patients from a prospective multicentre cohort of newly-diagnosed bladder cancer patients, followed-up for 4.33 +/- 1.71 years. We found IL-17-positive cells were significantly increased in primary and concomitant carcinoma in situ (CIS), p",

keywords = "BACILLUS-CALMETTE-GUERIN, CARCINOMA IN-SITU, COLORECTAL-CANCER, IL-17, PROGRESSION, RECURRENCE, EXPRESSION, CYTOKINES, INFLAMMATION, PSORIASIS",

author = "Dowell, {Alexander C.} and Ellen Cobby and Kaisheng Wen and Devall, {Adam J.} and Vinnie During and Jane Anderson and James, {Nicholas D.} and Cheng, {Kar K.} and Zeegers, {Maurice P.} and Bryan, {Richard T.} and Taylor, {Graham S.}",

year = "2017",

month = sep,

day = "20",

doi = "10.1371/journal.pone.0184841",

language = "English",

volume = "12",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "9",

}

Dowell, AC, Cobby, E, Wen, K, Devall, AJ, During, V, Anderson, J, James, ND, Cheng, KK, Zeegers, MP, Bryan, RT & Taylor, GS 2017, 'Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer', PLOS ONE, vol. 12, no. 9, 0184841. https://doi.org/10.1371/journal.pone.0184841

Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer. / Dowell, Alexander C.; Cobby, Ellen; Wen, Kaisheng et al.
In: PLOS ONE, Vol. 12, No. 9, 0184841, 20.09.2017.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS

T2 - Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer

AU - Dowell, Alexander C.

AU - Cobby, Ellen

AU - Wen, Kaisheng

AU - Devall, Adam J.

AU - During, Vinnie

AU - Anderson, Jane

AU - James, Nicholas D.

AU - Cheng, Kar K.

AU - Zeegers, Maurice P.

AU - Bryan, Richard T.

AU - Taylor, Graham S.

PY - 2017/9/20

Y1 - 2017/9/20

N2 - The tumour immune microenvironment is considered to influence cancer behaviour and outcome. Using a panel of markers for innate and adaptive immune cells we set out to characterise and understand the bladder tumour microenvironment of 114 patients from a prospective multicentre cohort of newly-diagnosed bladder cancer patients, followed-up for 4.33 +/- 1.71 years. We found IL-17-positive cells were significantly increased in primary and concomitant carcinoma in situ (CIS), p

AB - The tumour immune microenvironment is considered to influence cancer behaviour and outcome. Using a panel of markers for innate and adaptive immune cells we set out to characterise and understand the bladder tumour microenvironment of 114 patients from a prospective multicentre cohort of newly-diagnosed bladder cancer patients, followed-up for 4.33 +/- 1.71 years. We found IL-17-positive cells were significantly increased in primary and concomitant carcinoma in situ (CIS), p

KW - BACILLUS-CALMETTE-GUERIN

KW - CARCINOMA IN-SITU

KW - COLORECTAL-CANCER

KW - IL-17

KW - PROGRESSION

KW - RECURRENCE

KW - EXPRESSION

KW - CYTOKINES

KW - INFLAMMATION

KW - PSORIASIS

U2 - 10.1371/journal.pone.0184841

DO - 10.1371/journal.pone.0184841

M3 - Article

C2 - 28931051

SN - 1932-6203

VL - 12

JO - PLOS ONE

JF - PLOS ONE

IS - 9

M1 - 0184841

ER -