Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer

Alexander C. Dowell, Ellen Cobby, Kaisheng Wen, Adam J. Devall, Vinnie During, Jane Anderson, Nicholas D. James, Kar K. Cheng, Maurice P. Zeegers, Richard T. Bryan*, Graham S. Taylor

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Web of Science)

Abstract

The tumour immune microenvironment is considered to influence cancer behaviour and outcome. Using a panel of markers for innate and adaptive immune cells we set out to characterise and understand the bladder tumour microenvironment of 114 patients from a prospective multicentre cohort of newly-diagnosed bladder cancer patients, followed-up for 4.33 +/- 1.71 years. We found IL-17-positive cells were significantly increased in primary and concomitant carcinoma in situ (CIS), p

Original languageEnglish
Article number0184841
Number of pages17
JournalPLOS ONE
Volume12
Issue number9
DOIs
Publication statusPublished - 20 Sep 2017

Keywords

  • BACILLUS-CALMETTE-GUERIN
  • CARCINOMA IN-SITU
  • COLORECTAL-CANCER
  • IL-17
  • PROGRESSION
  • RECURRENCE
  • EXPRESSION
  • CYTOKINES
  • INFLAMMATION
  • PSORIASIS

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