TY - JOUR
T1 - Interhospital variation in surgical treatment of screen-detected breast cancer in the South of the Netherlands
AU - van der Veer, Eline L.
AU - Coolen, Angela M.P.
AU - Bluekens, Adriana M.J.
AU - Generaal, Manon I.
AU - Schipper, Robert Jan
AU - Setz-Pels, Wikke
AU - van Uden, Dominique J.P.
AU - Voogd, Adri C.
AU - Duijm, Lucien E.M.
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025/4/1
Y1 - 2025/4/1
N2 - Background: The effectiveness of the Dutch breast cancer screening programme depends on the quality of the full trajectory, from the first screening to the final treatment of a screen-detected breast cancer. Interhospital variation in breast cancer treatment has been explored by several studies, however, not specifically in a screen-detected breast cancer population. The current study compares the treatment strategies of women with screen-detected breast cancer between hospitals in the South of the Netherlands. Methods: A total of 1450 women with screen-detected breast cancer, who participated in the Dutch screening programme between January 2009 and July 2019, were included in this retrospective analysis of a prospectively obtained database. Breast cancer treatment (i.e. preoperative MRI, neoadjuvant systemic therapy and type and outcomes of surgery) was compared between hospitals using multivariate analysis. Results: Statistically significant interhospital variation was observed in the use of preoperative MRI (range 20.8–35.8 %, p < 0.001), neoadjuvant systemic therapy (range 4.0–13.3 %, p < 0.001) and breast conserving surgery (range 70.0–87.1 %, p < 0.001). These differences persisted after adjustment for case-mix. In patients with invasive breast cancer treated by breast conserving surgery, the mean volume of the resection specimen ranged from 381 to 541 ml between hospitals (p < 0.001). However, this was not accompanied by significant differences in the percentage of patients with positive resection margins (range 2.9–5.7 %, p = 0.34). Conclusions: We observed significant interhospital variation in the management of women with screen-detected breast cancer. Quality assurance in screen-detected breast cancer may reduce these differences, but evolving breast cancer care and more personalised approaches should be accounted for.
AB - Background: The effectiveness of the Dutch breast cancer screening programme depends on the quality of the full trajectory, from the first screening to the final treatment of a screen-detected breast cancer. Interhospital variation in breast cancer treatment has been explored by several studies, however, not specifically in a screen-detected breast cancer population. The current study compares the treatment strategies of women with screen-detected breast cancer between hospitals in the South of the Netherlands. Methods: A total of 1450 women with screen-detected breast cancer, who participated in the Dutch screening programme between January 2009 and July 2019, were included in this retrospective analysis of a prospectively obtained database. Breast cancer treatment (i.e. preoperative MRI, neoadjuvant systemic therapy and type and outcomes of surgery) was compared between hospitals using multivariate analysis. Results: Statistically significant interhospital variation was observed in the use of preoperative MRI (range 20.8–35.8 %, p < 0.001), neoadjuvant systemic therapy (range 4.0–13.3 %, p < 0.001) and breast conserving surgery (range 70.0–87.1 %, p < 0.001). These differences persisted after adjustment for case-mix. In patients with invasive breast cancer treated by breast conserving surgery, the mean volume of the resection specimen ranged from 381 to 541 ml between hospitals (p < 0.001). However, this was not accompanied by significant differences in the percentage of patients with positive resection margins (range 2.9–5.7 %, p = 0.34). Conclusions: We observed significant interhospital variation in the management of women with screen-detected breast cancer. Quality assurance in screen-detected breast cancer may reduce these differences, but evolving breast cancer care and more personalised approaches should be accounted for.
KW - Breast cancer
KW - Interhospital variations
KW - Screening
KW - Therapy
U2 - 10.1016/j.breast.2025.103886
DO - 10.1016/j.breast.2025.103886
M3 - Article
SN - 0960-9776
VL - 80
JO - Breast
JF - Breast
M1 - 103886
ER -