Interdisciplinary multimodality management of stage III nonsmall cell lung cancer

Rudolf M. Huber*, Dirk De Ruysscher, Hans Hoffmann, Simone Reu, Amanda Tufman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Web of Science)

Abstract

Stage III nonsmall cell lung cancer (NSCLC) comprises about one-third of NSCLC patients and is very heterogeneous with varying and mostly poor prognosis. It is also called "locoregionally or locally advanced disease". Due to its heterogeneity a general schematic management approach is not appropriate. Usually a combination of local therapy (surgery or radiotherapy, depending on functional, technical and oncological operability) with systemic platinum-based doublet chemotherapy and, recently, followed by immune therapy is used. A more aggressive approach of triple agent chemotherapy or two local therapies (surgery and radiotherapy, except for specific indications) has no benefit for overall survival. Until now tumour stage and the general condition of the patient are the most relevant prognostic factors. Characterising the tumour molecularly and immunologically may lead to a more personalised and effective approach. At the moment, after an exact staging and functional evaluation, an interdisciplinary discussion amongst the tumour board is warranted and offers the best management strategy.

Original languageEnglish
Article number190024
Number of pages13
JournalEuropean Respiratory Review
Volume28
Issue number152
DOIs
Publication statusPublished - 30 Jun 2019

Keywords

  • GROWTH-FACTOR-RECEPTOR
  • RANDOMIZED PHASE-III
  • LEUKEMIA-GROUP-B
  • HYPERFRACTIONATED RADIATION-THERAPY
  • INDIVIDUAL PATIENT DATA
  • INDUCTION CHEMOTHERAPY
  • CONCURRENT CHEMORADIOTHERAPY
  • PREOPERATIVE CHEMOTHERAPY
  • ACCELERATED RADIOTHERAPY
  • THORACIC RADIOTHERAPY

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