Interaction of brain 5-HT synthesis deficiency, chronic stress and sex differentially impact emotional behavior in Tph2 knockout mice

Lise Gutknecht, Sandy Popp, Jonas Waider, Frank M. J. Sommerlandt, Corinna Goeppner, Antonia Post, Andreas Reif, Daniel van den Hove, Tatyana Strekalova, Angelika Schmitt, Maria B. N. Colaco, Claudia Sommer, Rupert Palme, Klaus-Peter Lesch*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Web of Science)
Original languageEnglish
Pages (from-to)2429-2441
Issue number14
Publication statusPublished - Jul 2015


  • Serotonin
  • Tryptophan hydroxylase-2 (Tph2)
  • Chronic stress
  • Gene-by-environment interaction
  • Anxiety
  • Fear
  • Depression
  • Aggression

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