Interaction between plasma homocysteine and the MTHFR c.677C > T polymorphism is associated with site-specific changes in DNA methylation in humans

Alexander J Nash; Pooja R Mandaviya; Marie-Joe Dib; André G Uitterlinden; Joyce van Meurs; Sandra G Heil; Toby Andrew; Kourosh R Ahmadi

doi:10.1096/fj.201800400r

Interaction between plasma homocysteine and the MTHFR c.677C > T polymorphism is associated with site-specific changes in DNA methylation in humans

Alexander J Nash, Pooja R Mandaviya, Marie-Joe Dib, André G Uitterlinden, Joyce van Meurs, Sandra G Heil, Toby Andrew, Kourosh R Ahmadi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Web of Science)

Original language	English
Pages (from-to)	833-843
Number of pages	11
Journal	Faseb Journal
Volume	33
Issue number	1
DOIs	https://doi.org/10.1096/fj.201800400r
Publication status	Published - Jan 2019

Keywords

1-carbon metabolism
DEMENTIA
DETERMINANTS
EXPRESSION
FOLATE INTAKE
HYPERHOMOCYSTEINEMIA
HYPOMETHYLATION
METABOLISM
METHYLENETETRAHYDROFOLATE-REDUCTASE
NEPHROPATHY
RISK-FACTOR
epigenetics
methylenetetrahydrofolate reductase
methylome-wide association study
vascular disease

Access to Document

10.1096/fj.201800400r

Cite this

@article{70c5ab1bbb654d19b1ae5d5f256d8224,

title = "Interaction between plasma homocysteine and the MTHFR c.677C > T polymorphism is associated with site-specific changes in DNA methylation in humans",

keywords = "1-carbon metabolism, DEMENTIA, DETERMINANTS, EXPRESSION, FOLATE INTAKE, HYPERHOMOCYSTEINEMIA, HYPOMETHYLATION, METABOLISM, METHYLENETETRAHYDROFOLATE-REDUCTASE, NEPHROPATHY, RISK-FACTOR, epigenetics, methylenetetrahydrofolate reductase, methylome-wide association study, vascular disease",

author = "Nash, {Alexander J} and Mandaviya, {Pooja R} and Marie-Joe Dib and Uitterlinden, {Andr{\'e} G} and {van Meurs}, Joyce and Heil, {Sandra G} and Toby Andrew and Ahmadi, {Kourosh R}",

year = "2019",

month = jan,

doi = "10.1096/fj.201800400r",

language = "English",

volume = "33",

pages = "833--843",

journal = "Faseb Journal",

issn = "0892-6638",

publisher = "FASEB",

number = "1",

}

Interaction between plasma homocysteine and the MTHFR c.677C > T polymorphism is associated with site-specific changes in DNA methylation in humans. / Nash, Alexander J; Mandaviya, Pooja R; Dib, Marie-Joe; Uitterlinden, André G; van Meurs, Joyce; Heil, Sandra G; Andrew, Toby; Ahmadi, Kourosh R.

In: Faseb Journal, Vol. 33, No. 1, 01.2019, p. 833-843.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Interaction between plasma homocysteine and the MTHFR c.677C > T polymorphism is associated with site-specific changes in DNA methylation in humans

AU - Nash, Alexander J

AU - Mandaviya, Pooja R

AU - Dib, Marie-Joe

AU - Uitterlinden, André G

AU - van Meurs, Joyce

AU - Heil, Sandra G

AU - Andrew, Toby

AU - Ahmadi, Kourosh R

PY - 2019/1

Y1 - 2019/1

KW - 1-carbon metabolism

KW - DEMENTIA

KW - DETERMINANTS

KW - EXPRESSION

KW - FOLATE INTAKE

KW - HYPERHOMOCYSTEINEMIA

KW - HYPOMETHYLATION

KW - METABOLISM

KW - METHYLENETETRAHYDROFOLATE-REDUCTASE

KW - NEPHROPATHY

KW - RISK-FACTOR

KW - epigenetics

KW - methylenetetrahydrofolate reductase

KW - methylome-wide association study

KW - vascular disease

U2 - 10.1096/fj.201800400r

DO - 10.1096/fj.201800400r

M3 - Article

C2 - 30080444

VL - 33

SP - 833

EP - 843

JO - Faseb Journal

JF - Faseb Journal

SN - 0892-6638

IS - 1

ER -