Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution

Adel Boueiz, Betty Pham, Robert Chase, Andrew Lamb, Sool Lee, Zun Zar Chi Naing, Michael Cho, Margaret M. Parker, Phuwanat Sakornsakolpat, Craig P. Hersh, James D. Crapo, Andrew B. Stergachis, Ruth Tal-Singer, Dawn L. DeMeo, Edwin K. Silverman, Xiaobo Zhou, Peter J. Castaldi*, ECLIPSE Investigators, Emiel Wouters

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)388-398
Number of pages11
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume60
Issue number4
DOIs
Publication statusPublished - Apr 2019

Keywords

  • integrative genomics
  • emphysema distribution
  • chronic obstructive pulmonary disease
  • ACVR1B gene
  • transforming growth factor-beta signaling
  • LUNG-VOLUME-REDUCTION
  • OBSTRUCTIVE PULMONARY-DISEASE
  • WIDE ASSOCIATION
  • EXPRESSION
  • LANDSCAPE
  • GWAS

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