Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.: Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.

Elisabeth M Lodder; Brendon P Scicluna; Leander Beekman; Danny Arends; Perry D Moerland; Michael W Tanck; Michiel E Adriaens; Connie R Bezzina

doi:10.1161/CIRCGENETICS.114.000537

Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.

Elisabeth M Lodder, Brendon P Scicluna, Leander Beekman, Danny Arends, Perry D Moerland, Michael W Tanck, Michiel E Adriaens, Connie R Bezzina^*

^*Corresponding author for this work

MaCSBio | Faculty of Science and Engineering

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

With aging and in cardiac disease, fibrosis caused by collagen deposition is increased, impairing contractility and providing a substrate for arrhythmia. In this study, we set out to identify genetic modifiers of collagen deposition in the heart by exploiting the genetic variability among F2 progeny of 129P2 and FVBN/J mice carrying the Scn5a(tm1Care/+) mutation.

Original language	English
Pages (from-to)	790-798
Number of pages	9
Journal	Circulation : Cardiovascular Genetics
Volume	7
Issue number	6
DOIs	https://doi.org/10.1161/CIRCGENETICS.114.000537
Publication status	Published - 2014

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10.1161/CIRCGENETICS.114.000537

Cite this

Lodder, E. M., Scicluna, B. P., Beekman, L., Arends, D., Moerland, P. D., Tanck, M. W., Adriaens, M. E., & Bezzina, C. R. (2014). Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Circulation : Cardiovascular Genetics, 7(6), 790-798. https://doi.org/10.1161/CIRCGENETICS.114.000537

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title = "Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.: Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.",

abstract = "With aging and in cardiac disease, fibrosis caused by collagen deposition is increased, impairing contractility and providing a substrate for arrhythmia. In this study, we set out to identify genetic modifiers of collagen deposition in the heart by exploiting the genetic variability among F2 progeny of 129P2 and FVBN/J mice carrying the Scn5a(tm1Care/+) mutation.",

author = "Lodder, {Elisabeth M} and Scicluna, {Brendon P} and Leander Beekman and Danny Arends and Moerland, {Perry D} and Tanck, {Michael W} and Adriaens, {Michiel E} and Bezzina, {Connie R}",

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language = "English",

volume = "7",

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Lodder, EM, Scicluna, BP, Beekman, L, Arends, D, Moerland, PD, Tanck, MW, Adriaens, ME & Bezzina, CR 2014, 'Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.', Circulation : Cardiovascular Genetics, vol. 7, no. 6, pp. 790-798. https://doi.org/10.1161/CIRCGENETICS.114.000537

Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. / Lodder, Elisabeth M; Scicluna, Brendon P; Beekman, Leander et al.
In: Circulation : Cardiovascular Genetics, Vol. 7, No. 6, 2014, p. 790-798.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Moerland, Perry D

AU - Tanck, Michael W

AU - Adriaens, Michiel E

AU - Bezzina, Connie R

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