With aging and in cardiac disease, fibrosis caused by collagen deposition is increased, impairing contractility and providing a substrate for arrhythmia. In this study, we set out to identify genetic modifiers of collagen deposition in the heart by exploiting the genetic variability among F2 progeny of 129P2 and FVBN/J mice carrying the Scn5a(tm1Care/+) mutation.
Lodder, E. M., Scicluna, B. P., Beekman, L., Arends, D., Moerland, P. D., Tanck, M. W., Adriaens, M. E., & Bezzina, C. R. (2014). Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Circulation : Cardiovascular Genetics, 7(6), 790-798. https://doi.org/10.1161/CIRCGENETICS.114.000537