Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.

Elisabeth M Lodder, Brendon P Scicluna, Leander Beekman, Danny Arends, Perry D Moerland, Michael W Tanck, Michiel E Adriaens, Connie R Bezzina

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

With aging and in cardiac disease, fibrosis caused by collagen deposition is increased, impairing contractility and providing a substrate for arrhythmia. In this study, we set out to identify genetic modifiers of collagen deposition in the heart by exploiting the genetic variability among F2 progeny of 129P2 and FVBN/J mice carrying the Scn5a(tm1Care/+) mutation.
Original languageEnglish
Pages (from-to)790-798
Number of pages9
JournalCirculation : Cardiovascular Genetics
Volume7
Issue number6
DOIs
Publication statusPublished - 2014

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