Integration of Electrical, Structural, and Anatomical imaging for the guidance of Cardiac Resynchronization Therapy

U.C. Nguyen; M.J.M. Cluitmans; C. Mihl; J.J.G. Luermans; B.L.J.H. Kietselaer; S.C.A.M. Bekkers; S. Gommers; P.G.A. Volders; F.W. Prinzen; K. Vernooy

doi:10.22489/CinC.2017.044-466

Integration of Electrical, Structural, and Anatomical imaging for the guidance of Cardiac Resynchronization Therapy

U.C. Nguyen^*
, M.J.M. Cluitmans
, C. Mihl
, J.J.G. Luermans
, B.L.J.H. Kietselaer
, S.C.A.M. Bekkers
, S. Gommers
, P.G.A. Volders
, F.W. Prinzen
, K. Vernooy

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

Abstract

Background: Placing the left ventricular (LV) lead at a site of late electrical activation remote from scar is desired for cardiac resynchronization therapy (CRT) response.Objective: The purpose of this study was to integrate electrocardiographic imaging (ECGi) with computed tomography (CT) derived coronary venous anatomy and delayed enhancement cardiac magnetic resonance imaging (DE-CMR) derived scar to reconstruct a pre-procedural roadmap for LV lead guidance in CRT.Methods: Three CRT candidates with focal scar defined by DE-CMR were prospectively included. Intrinsic body surface potentials measurements (BSPM) were carried out. Inverse reconstruction using the CT heart-torso geometry were used for ECGi. Meshes of the CT coronary veins, epicardium with ECGi activation times, and DE-CMR scar were integrated.Results: The ECGi-CT-CMR roadmap was used for CRT implantation in 2/3 patients. Placing the LV lead remote from scar was accomplished in 2/2 patients. Target veins from the ECGi-CT-CMR roadmap were located in a region of 80-105 ms electrical delay.Conclusion: ECGi-CT-CMR roadmaps can be used during CRT implantation to guide LV lead placement to a coronary vein remote from scar in a region of late electrical activation, possibly improving CRT.

Original language	English
Title of host publication	2017 COMPUTING IN CARDIOLOGY (CINC)
Publisher	IEEE Computer Society
Pages	1-4
Number of pages	4
Volume	44
DOIs	https://doi.org/10.22489/CinC.2017.044-466
Publication status	Published - 2017
Event	44th Computing in Cardiology Conference - Rennes, France Duration: 24 Sept 2017 → 27 Sept 2017 https://www.cinc.org/2017/ProgramBook/2017CinCProgramBook2.pdf

Publication series

Series	Computing in Cardiology Conference
Volume	44
ISSN	2325-8861

Conference

Conference	44th Computing in Cardiology Conference
Abbreviated title	CinC
Country/Territory	France
City	Rennes
Period	24/09/17 → 27/09/17
Internet address	https://www.cinc.org/2017/ProgramBook/2017CinCProgramBook2.pdf

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10.22489/CinC.2017.044-466

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Nguyen, U. C., Cluitmans, M. J. M., Mihl, C., Luermans, J. J. G., Kietselaer, B. L. J. H., Bekkers, S. C. A. M., Gommers, S., Volders, P. G. A., Prinzen, F. W., & Vernooy, K. (2017). Integration of Electrical, Structural, and Anatomical imaging for the guidance of Cardiac Resynchronization Therapy. In 2017 COMPUTING IN CARDIOLOGY (CINC) (Vol. 44, pp. 1-4). IEEE Computer Society. https://doi.org/10.22489/CinC.2017.044-466

@inproceedings{685c7fd4c630472faba6211b0074ee74,

title = "Integration of Electrical, Structural, and Anatomical imaging for the guidance of Cardiac Resynchronization Therapy",

abstract = "Background: Placing the left ventricular (LV) lead at a site of late electrical activation remote from scar is desired for cardiac resynchronization therapy (CRT) response.Objective: The purpose of this study was to integrate electrocardiographic imaging (ECGi) with computed tomography (CT) derived coronary venous anatomy and delayed enhancement cardiac magnetic resonance imaging (DE-CMR) derived scar to reconstruct a pre-procedural roadmap for LV lead guidance in CRT.Methods: Three CRT candidates with focal scar defined by DE-CMR were prospectively included. Intrinsic body surface potentials measurements (BSPM) were carried out. Inverse reconstruction using the CT heart-torso geometry were used for ECGi. Meshes of the CT coronary veins, epicardium with ECGi activation times, and DE-CMR scar were integrated.Results: The ECGi-CT-CMR roadmap was used for CRT implantation in 2/3 patients. Placing the LV lead remote from scar was accomplished in 2/2 patients. Target veins from the ECGi-CT-CMR roadmap were located in a region of 80-105 ms electrical delay.Conclusion: ECGi-CT-CMR roadmaps can be used during CRT implantation to guide LV lead placement to a coronary vein remote from scar in a region of late electrical activation, possibly improving CRT.",

author = "U.C. Nguyen and M.J.M. Cluitmans and C. Mihl and J.J.G. Luermans and B.L.J.H. Kietselaer and S.C.A.M. Bekkers and S. Gommers and P.G.A. Volders and F.W. Prinzen and K. Vernooy",

year = "2017",

doi = "10.22489/CinC.2017.044-466",

language = "English",

volume = "44",

series = "Computing in Cardiology Conference",

publisher = "IEEE Computer Society",

pages = "1--4",

booktitle = "2017 COMPUTING IN CARDIOLOGY (CINC)",

address = "United States",

note = "44th Computing in Cardiology Conference , CinC ; Conference date: 24-09-2017 Through 27-09-2017",

url = "https://www.cinc.org/2017/ProgramBook/2017CinCProgramBook2.pdf",

}

Nguyen, UC , Cluitmans, MJM , Mihl, C , Luermans, JJG, Kietselaer, BLJH, Bekkers, SCAM, Gommers, S , Volders, PGA , Prinzen, FW & Vernooy, K 2017, Integration of Electrical, Structural, and Anatomical imaging for the guidance of Cardiac Resynchronization Therapy. in 2017 COMPUTING IN CARDIOLOGY (CINC). vol. 44, IEEE Computer Society, Computing in Cardiology Conference, vol. 44, pp. 1-4, 44th Computing in Cardiology Conference , Rennes, France, 24/09/17. https://doi.org/10.22489/CinC.2017.044-466

Integration of Electrical, Structural, and Anatomical imaging for the guidance of Cardiac Resynchronization Therapy. / Nguyen, U.C.; Cluitmans, M.J.M.; Mihl, C. et al.
2017 COMPUTING IN CARDIOLOGY (CINC). Vol. 44 IEEE Computer Society, 2017. p. 1-4 (Computing in Cardiology Conference, Vol. 44).

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

TY - GEN

T1 - Integration of Electrical, Structural, and Anatomical imaging for the guidance of Cardiac Resynchronization Therapy

AU - Nguyen, U.C.

AU - Cluitmans, M.J.M.

AU - Mihl, C.

AU - Luermans, J.J.G.

AU - Kietselaer, B.L.J.H.

AU - Bekkers, S.C.A.M.

AU - Gommers, S.

AU - Volders, P.G.A.

AU - Prinzen, F.W.

AU - Vernooy, K.

PY - 2017

Y1 - 2017

N2 - Background: Placing the left ventricular (LV) lead at a site of late electrical activation remote from scar is desired for cardiac resynchronization therapy (CRT) response.Objective: The purpose of this study was to integrate electrocardiographic imaging (ECGi) with computed tomography (CT) derived coronary venous anatomy and delayed enhancement cardiac magnetic resonance imaging (DE-CMR) derived scar to reconstruct a pre-procedural roadmap for LV lead guidance in CRT.Methods: Three CRT candidates with focal scar defined by DE-CMR were prospectively included. Intrinsic body surface potentials measurements (BSPM) were carried out. Inverse reconstruction using the CT heart-torso geometry were used for ECGi. Meshes of the CT coronary veins, epicardium with ECGi activation times, and DE-CMR scar were integrated.Results: The ECGi-CT-CMR roadmap was used for CRT implantation in 2/3 patients. Placing the LV lead remote from scar was accomplished in 2/2 patients. Target veins from the ECGi-CT-CMR roadmap were located in a region of 80-105 ms electrical delay.Conclusion: ECGi-CT-CMR roadmaps can be used during CRT implantation to guide LV lead placement to a coronary vein remote from scar in a region of late electrical activation, possibly improving CRT.

AB - Background: Placing the left ventricular (LV) lead at a site of late electrical activation remote from scar is desired for cardiac resynchronization therapy (CRT) response.Objective: The purpose of this study was to integrate electrocardiographic imaging (ECGi) with computed tomography (CT) derived coronary venous anatomy and delayed enhancement cardiac magnetic resonance imaging (DE-CMR) derived scar to reconstruct a pre-procedural roadmap for LV lead guidance in CRT.Methods: Three CRT candidates with focal scar defined by DE-CMR were prospectively included. Intrinsic body surface potentials measurements (BSPM) were carried out. Inverse reconstruction using the CT heart-torso geometry were used for ECGi. Meshes of the CT coronary veins, epicardium with ECGi activation times, and DE-CMR scar were integrated.Results: The ECGi-CT-CMR roadmap was used for CRT implantation in 2/3 patients. Placing the LV lead remote from scar was accomplished in 2/2 patients. Target veins from the ECGi-CT-CMR roadmap were located in a region of 80-105 ms electrical delay.Conclusion: ECGi-CT-CMR roadmaps can be used during CRT implantation to guide LV lead placement to a coronary vein remote from scar in a region of late electrical activation, possibly improving CRT.

U2 - 10.22489/CinC.2017.044-466

DO - 10.22489/CinC.2017.044-466

M3 - Conference article in proceeding

VL - 44

T3 - Computing in Cardiology Conference

SP - 1

EP - 4

BT - 2017 COMPUTING IN CARDIOLOGY (CINC)

PB - IEEE Computer Society

T2 - 44th Computing in Cardiology Conference

Y2 - 24 September 2017 through 27 September 2017

ER -

Integration of Electrical, Structural, and Anatomical imaging for the guidance of Cardiac Resynchronization Therapy

Abstract

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