Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

Keyphrases

• Transcriptomics 100%
• Mode of Action 100%
• HepG2 Cells 100%
• Metabonomics 100%
• 2,3,7,8-tetrachlorodibenzo-p-dioxin 100%
• HepG2 50%
• Pathway Map 50%
• Son of Sevenless 50%
• Amino Acid Metabolism 25%
• Genome Analysis 25%
• Omics Technologies 25%
• Omics 25%
• Molecular Response 25%
• Transcriptome Analysis 25%
• Molecular Mechanism 25%
• In Vitro Study 25%
• Oncogenesis 25%
• Receptor-interacting Protein Kinase 1 (RIPK1) 25%
• Metabolic Processes 25%
• G Protein-coupled Receptor 25%
• Cellular Response 25%
• Small GTPase 25%
• Receptor-mediated 25%
• Human Cells 25%
• Environmental Carcinogens 25%
• Dioxin Exposure 25%
• Protein Signaling Pathways 25%
• Animal-based 25%
• Alternatives to Animals 25%
• Toxicity Assay 25%
• Human Hepatocarcinoma Cell Line 25%
• Nongenotoxic Carcinogenesis 25%
• Cross-omics Analysis 25%
• Toxic Chemicals 25%
• Upregulated Genes 25%
• In Vitro Cell Models 25%

INIS

• toxicity 100%
• dioxin 100%
• in vitro 75%
• receptors 50%
• maps 50%
• in vivo 50%
• carcinogenesis 50%
• data 25%
• humans 25%
• animals 25%
• genes 25%
• amino acids 25%
• metabolism 25%
• proteins 25%
• hypothesis 25%
• carcinogens 25%
• g-proteins 25%
• human cells 25%

Pharmacology, Toxicology and Pharmaceutical Science

• 2,3,7,8-Tetrachlorodibenzodioxin 100%
• Tamsulosin 75%
• Carcinogenesis 50%
• Carcinogen 25%
• Liver Cell Carcinoma 25%
• Receptor 25%
• Amino Acid 25%
• Toxic Substance 25%
• G Protein Coupled Receptor 25%
• Receptor Protein 25%