Intact hemisphere and corpus callosum compensate for visuomotor functions after early visual cortex damage

Alessia Celeghin, Matteo Diano, Beatrice de Gelder, Lawrence Weiskrantz, Carlo A Marzi, Marco Tamietto

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Unilateral damage to the primary visual cortex (V1) leads to clinical blindness in the opposite visual hemifield, yet nonconscious ability to transform unseen visual input into motor output can be retained, a condition known as "blindsight." Here we combined psychophysics, functional magnetic resonance imaging, and tractography to investigate the functional and structural properties that enable the developing brain to partly overcome the effects of early V1 lesion in one blindsight patient. Visual stimuli appeared in either the intact or blind hemifield and simple responses were given with either the left or right hand, thereby creating conditions where visual input and motor output involve the same or opposite hemisphere. When the V1-damaged hemisphere was challenged by incoming visual stimuli, or controlled manual responses to these unseen stimuli, the corpus callosum (CC) dynamically recruited areas in the visual dorsal stream and premotor cortex of the intact hemisphere to compensate for altered visuomotor functions. These compensatory changes in functional brain activity were paralleled by increased connections in posterior regions of the CC, where fibers connecting homologous areas of the parietal cortex course.

Original languageEnglish
Pages (from-to)E10475-E10483
Number of pages9
JournalProceedings of the National Academy of Sciences of the United States of America
Volume114
Issue number48
DOIs
Publication statusPublished - 28 Nov 2017

Keywords

  • Journal Article
  • INTERHEMISPHERIC-TRANSFER
  • ACTIVATION
  • WHITE-MATTER
  • VISION
  • blindsight
  • plasticity
  • SIMPLE REACTION-TIMES
  • ORGANIZATION
  • NEURONAL RESPONSES
  • tractography
  • Poffenberger
  • TRACTOGRAPHY
  • MOTOR
  • corpus callosum
  • FMRI

Cite this

Celeghin, Alessia ; Diano, Matteo ; de Gelder, Beatrice ; Weiskrantz, Lawrence ; Marzi, Carlo A ; Tamietto, Marco. / Intact hemisphere and corpus callosum compensate for visuomotor functions after early visual cortex damage. In: Proceedings of the National Academy of Sciences of the United States of America. 2017 ; Vol. 114, No. 48. pp. E10475-E10483.
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abstract = "Unilateral damage to the primary visual cortex (V1) leads to clinical blindness in the opposite visual hemifield, yet nonconscious ability to transform unseen visual input into motor output can be retained, a condition known as {"}blindsight.{"} Here we combined psychophysics, functional magnetic resonance imaging, and tractography to investigate the functional and structural properties that enable the developing brain to partly overcome the effects of early V1 lesion in one blindsight patient. Visual stimuli appeared in either the intact or blind hemifield and simple responses were given with either the left or right hand, thereby creating conditions where visual input and motor output involve the same or opposite hemisphere. When the V1-damaged hemisphere was challenged by incoming visual stimuli, or controlled manual responses to these unseen stimuli, the corpus callosum (CC) dynamically recruited areas in the visual dorsal stream and premotor cortex of the intact hemisphere to compensate for altered visuomotor functions. These compensatory changes in functional brain activity were paralleled by increased connections in posterior regions of the CC, where fibers connecting homologous areas of the parietal cortex course.",
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author = "Alessia Celeghin and Matteo Diano and {de Gelder}, Beatrice and Lawrence Weiskrantz and Marzi, {Carlo A} and Marco Tamietto",
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Intact hemisphere and corpus callosum compensate for visuomotor functions after early visual cortex damage. / Celeghin, Alessia; Diano, Matteo; de Gelder, Beatrice; Weiskrantz, Lawrence; Marzi, Carlo A; Tamietto, Marco.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 48, 28.11.2017, p. E10475-E10483.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Intact hemisphere and corpus callosum compensate for visuomotor functions after early visual cortex damage

AU - Celeghin, Alessia

AU - Diano, Matteo

AU - de Gelder, Beatrice

AU - Weiskrantz, Lawrence

AU - Marzi, Carlo A

AU - Tamietto, Marco

N1 - Copyright © 2017 the Author(s). Published by PNAS.

PY - 2017/11/28

Y1 - 2017/11/28

N2 - Unilateral damage to the primary visual cortex (V1) leads to clinical blindness in the opposite visual hemifield, yet nonconscious ability to transform unseen visual input into motor output can be retained, a condition known as "blindsight." Here we combined psychophysics, functional magnetic resonance imaging, and tractography to investigate the functional and structural properties that enable the developing brain to partly overcome the effects of early V1 lesion in one blindsight patient. Visual stimuli appeared in either the intact or blind hemifield and simple responses were given with either the left or right hand, thereby creating conditions where visual input and motor output involve the same or opposite hemisphere. When the V1-damaged hemisphere was challenged by incoming visual stimuli, or controlled manual responses to these unseen stimuli, the corpus callosum (CC) dynamically recruited areas in the visual dorsal stream and premotor cortex of the intact hemisphere to compensate for altered visuomotor functions. These compensatory changes in functional brain activity were paralleled by increased connections in posterior regions of the CC, where fibers connecting homologous areas of the parietal cortex course.

AB - Unilateral damage to the primary visual cortex (V1) leads to clinical blindness in the opposite visual hemifield, yet nonconscious ability to transform unseen visual input into motor output can be retained, a condition known as "blindsight." Here we combined psychophysics, functional magnetic resonance imaging, and tractography to investigate the functional and structural properties that enable the developing brain to partly overcome the effects of early V1 lesion in one blindsight patient. Visual stimuli appeared in either the intact or blind hemifield and simple responses were given with either the left or right hand, thereby creating conditions where visual input and motor output involve the same or opposite hemisphere. When the V1-damaged hemisphere was challenged by incoming visual stimuli, or controlled manual responses to these unseen stimuli, the corpus callosum (CC) dynamically recruited areas in the visual dorsal stream and premotor cortex of the intact hemisphere to compensate for altered visuomotor functions. These compensatory changes in functional brain activity were paralleled by increased connections in posterior regions of the CC, where fibers connecting homologous areas of the parietal cortex course.

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JF - Proceedings of the National Academy of Sciences of the United States of America

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