TY - JOUR
T1 - Instrumental Assessment of Bradykinesia: A Comparison Between Motor Tasks
AU - Mentzel, Thierry Q.
AU - Mentzel, Charlotte
AU - Mentzel, Stijn V.
AU - Lieverse, Ritsaert
AU - Daanen, Hein A. M.
AU - van Harten, Peter N.
PY - 2016/3
Y1 - 2016/3
N2 - Bradykinesia, a common symptom in psychiatry, is characterized by reduced movement speed and amplitude. Monitoring for bradykinesia is important, as it has been associated with reductions in quality of life and medication compliance. Subtle forms of bradykinesia have been associated with treatment response in antipsychotic-naive first episode patients. Therefore, accurate and reliable assessment is of clinical importance. Several mechanical and electronic instruments have been developed for this purpose. However, their content validity is limited. This study investigated which tasks, or combinations thereof, are most suitable for assessing bradykinesia instrumentally. Eleven motor tasks were assessed using inertial sensors. Their capability of distinguishing bradykinetic patients with schizophrenia (n = 6) from healthy controls (n = 5) was investigated. Seven tasks significantly discriminated patients from controls. The combination of tasks considered most feasible for the instrumental assessment of bradykinesia was the gait, pronation/supination, leg agility and flexion/extension of elbow tasks (effect size = 2.9).
AB - Bradykinesia, a common symptom in psychiatry, is characterized by reduced movement speed and amplitude. Monitoring for bradykinesia is important, as it has been associated with reductions in quality of life and medication compliance. Subtle forms of bradykinesia have been associated with treatment response in antipsychotic-naive first episode patients. Therefore, accurate and reliable assessment is of clinical importance. Several mechanical and electronic instruments have been developed for this purpose. However, their content validity is limited. This study investigated which tasks, or combinations thereof, are most suitable for assessing bradykinesia instrumentally. Eleven motor tasks were assessed using inertial sensors. Their capability of distinguishing bradykinetic patients with schizophrenia (n = 6) from healthy controls (n = 5) was investigated. Seven tasks significantly discriminated patients from controls. The combination of tasks considered most feasible for the instrumental assessment of bradykinesia was the gait, pronation/supination, leg agility and flexion/extension of elbow tasks (effect size = 2.9).
KW - Antipsychotic-induced
KW - bradykinesia
KW - instrumental assessment
KW - motor task
KW - schizophrenia & psychotic states
U2 - 10.1109/JBHI.2015.2412656
DO - 10.1109/JBHI.2015.2412656
M3 - Article
C2 - 25823047
SN - 2168-2194
VL - 20
SP - 521
EP - 526
JO - IEEE Journal of Biomedical and Health Informatics
JF - IEEE Journal of Biomedical and Health Informatics
IS - 2
ER -