INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology

Pieter-Jan D. Guns*, Brian D. Guth, Stefan Braam, Georgios Kosmidis, Elena Matsa, Annie Delaunois, Vitalina Gryshkova, Sylvain Bernasconi, Harm J. Knot, Yair Shemesh, Alon Chen, Michael Markert, Miguel A. Fernandez, Damiano Lombardi, Celine Grandmont, Berta Cillero-Pastor, Ron M. A. Heeren, Wim Martinet, Jeanette Woolard, Matt SkinnerVincent F. M. Segers, Constantijn Franssen, Emeline M. Van Craenenbroeck, Paul G. A. Volders, Thomas Pauwelyn, Dries Braeken, Paz Yanez, Krystle Correll, Xi Yang, Helen Prior, Gabor Kismihok, Guido R. Y. De Meyer, Jean-Pierre Valentin

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Safety pharmacology is an essential part of drug development aiming to identify, evaluate and investigate undesirable pharmacodynamic properties of a drug primarily prior to clinical trials. In particular, cardiovascular adverse drug reactions (ADR) have halted many drug development programs. Safety pharmacology has successfully implemented a screening strategy to detect cardiovascular liabilities, but there is room for further refinement. In this setting, we present the INSPIRE project, a European Training Network in safety pharmacology for Early Stage Researchers (ESRs), funded by the European Commission's H2020-MSCA-ITN programme. INSPIRE has recruited 15 ESR fellows that will conduct an individual PhD-research project for a period of 36 months. INSPIRE aims to be complementary to ongoing research initiatives. With this as a goal, an inventory of collaborative research initiatives in safety pharmacology was created and the ESR projects have been designed to be complementary to this roadmap. Overall, INSPIRE aims to improve cardiovascular safety evaluation, either by investigating technological innovations or by adding mechanistic insight in emerging safety concerns, as observed in the field of cardio-oncology. Finally, in addition to its hands-on research pillar, INSPIRE will organize a number of summer schools and workshops that will be open to the wider community as well. In summary, INSPIRE aims to foster both research and training in safety pharmacology and hopes to inspire the future generation of safety scientists.

Original languageEnglish
Article number106889
Number of pages10
JournalJournal of Pharmacological and Toxicological Methods
Volume105
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Safety pharmacology
  • Cardiovascular safety liabilities
  • Cardio-oncology
  • Drug development
  • Training and education
  • Methods
  • Marie Sklodowska-curie actions
  • CELL-DERIVED CARDIOMYOCYTES
  • CLINICAL-TRIALS
  • PRESSURE
  • PARADIGM
  • RODENTS

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