Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura

Bogac Ercig, Kanin Wichapong, Chris P. M. Reutelingsperger, Karen Vanhoorelbeke, Jan Voorberg, Gerry A. F. Nicolaes

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)28-41
Number of pages14
JournalThrombosis and Haemostasis
Volume118
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • ADAMTS13
  • von Willebrand factor
  • thrombosis
  • thrombotic thrombocytopenic purpura
  • autoimmune diseases
  • VON-WILLEBRAND-FACTOR
  • FACTOR-CLEAVING PROTEASE
  • UPSHAW-SCHULMAN-SYNDROME
  • HUMAN NEUTROPHIL PEPTIDES
  • DISINTEGRIN-LIKE DOMAIN
  • SPACER DOMAIN
  • CRYSTAL-STRUCTURES
  • BINDING-SITE
  • CONFORMATIONAL ACTIVATION
  • METALLOPROTEASE DOMAIN

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