Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction

Hamidreza Jafarinia; Ali Khalilimeybodi; Jorge Barrasa-Fano; Stephanie I. Fraley; Padmini Rangamani; Aurelie Carlier

doi:10.1038/s41540-024-00414-9

Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction

Hamidreza Jafarinia
, Ali Khalilimeybodi
, Jorge Barrasa-Fano
, Stephanie I. Fraley
, Padmini Rangamani^*
, Aurelie Carlier^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.

Original language	English
Article number	90
Number of pages	14
Journal	NPJ systems biology and applications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41540-024-00414-9
Publication status	Published - 15 Aug 2024

Keywords

FOCAL ADHESION KINASE
HIPPO PATHWAY
FORCE TRANSMISSION
LIGAND-BINDING
E-CADHERIN
YAP
TRACTION
ACTIVATION
LOCALIZATION
COMPLEX

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title = "Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction",

abstract = "YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.",

keywords = "FOCAL ADHESION KINASE, HIPPO PATHWAY, FORCE TRANSMISSION, LIGAND-BINDING, E-CADHERIN, YAP, TRACTION, ACTIVATION, LOCALIZATION, COMPLEX",

author = "Hamidreza Jafarinia and Ali Khalilimeybodi and Jorge Barrasa-Fano and Fraley, \{Stephanie I.\} and Padmini Rangamani and Aurelie Carlier",

year = "2024",

month = aug,

day = "15",

doi = "10.1038/s41540-024-00414-9",

language = "English",

volume = "10",

journal = "NPJ systems biology and applications",

issn = "2056-7189",

publisher = "Nature Publishing Group",

number = "1",

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TY - JOUR

T1 - Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction

AU - Jafarinia, Hamidreza

AU - Khalilimeybodi, Ali

AU - Barrasa-Fano, Jorge

AU - Fraley, Stephanie I.

AU - Rangamani, Padmini

AU - Carlier, Aurelie

PY - 2024/8/15

Y1 - 2024/8/15

N2 - YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.

AB - YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.

KW - FOCAL ADHESION KINASE

KW - HIPPO PATHWAY

KW - FORCE TRANSMISSION

KW - LIGAND-BINDING

KW - E-CADHERIN

KW - YAP

KW - TRACTION

KW - ACTIVATION

KW - LOCALIZATION

KW - COMPLEX

U2 - 10.1038/s41540-024-00414-9

DO - 10.1038/s41540-024-00414-9

M3 - (Systematic) Review article

SN - 2056-7189

VL - 10

JO - NPJ systems biology and applications

JF - NPJ systems biology and applications

IS - 1

M1 - 90

ER -

Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction

Abstract

Keywords

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