Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes

Kinga Oravecz; Anita Kormos; Andrea Gruber; Zoltan Marton; Zsofia Kohajda; Leila Mirzaei; Norbert Jost; Jouko Levijoki; Piero Pollesello; Tuula Koskelainen; Leena Otsomaa; Andras Toth; Julius Gy. Papp; Peter P. Nanasi; Gudrun Antoons; Andras Varro; Karoly Acsai; Norbert Nagy

doi:10.1016/j.ejphar.2017.10.039

Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes

Kinga Oravecz, Anita Kormos, Andrea Gruber, Zoltan Marton, Zsofia Kohajda, Leila Mirzaei, Norbert Jost, Jouko Levijoki, Piero Pollesello, Tuula Koskelainen, Leena Otsomaa, Andras Toth, Julius Gy. Papp, Peter P. Nanasi, Gudrun Antoons, Andras Varro^*, Karoly Acsai, Norbert Nagy

^*Corresponding author for this work

Fysiologie

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Web of Science)

Original language	English
Pages (from-to)	278-286
Number of pages	9
Journal	European Journal of Pharmacology
Volume	818
DOIs	https://doi.org/10.1016/j.ejphar.2017.10.039
Publication status	Published - 5 Jan 2018

Keywords

Cardiac inotropy
Ca2+ handling
NCX inhibition
ORM-10962
SODIUM-CALCIUM EXCHANGE
NA+/CA2+ EXCHANGER
NA+-CA2+ EXCHANGE
CA2+ CURRENT
SARCOPLASMIC-RETICULUM
HEART-FAILURE
TRANSPORT
CONTRACTILITY
KB-R7943
RELEASE

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10.1016/j.ejphar.2017.10.039

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Oravecz, K., Kormos, A., Gruber, A., Marton, Z., Kohajda, Z., Mirzaei, L., Jost, N., Levijoki, J., Pollesello, P., Koskelainen, T., Otsomaa, L., Toth, A., Papp, J. G., Nanasi, P. P., Antoons, G., Varro, A., Acsai, K., & Nagy, N. (2018). Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. European Journal of Pharmacology, 818, 278-286. https://doi.org/10.1016/j.ejphar.2017.10.039

Oravecz, Kinga ; Kormos, Anita ; Gruber, Andrea ; Marton, Zoltan ; Kohajda, Zsofia ; Mirzaei, Leila ; Jost, Norbert ; Levijoki, Jouko ; Pollesello, Piero ; Koskelainen, Tuula ; Otsomaa, Leena ; Toth, Andras ; Papp, Julius Gy. ; Nanasi, Peter P. ; Antoons, Gudrun ; Varro, Andras ; Acsai, Karoly ; Nagy, Norbert. / Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. In: European Journal of Pharmacology. 2018 ; Vol. 818. pp. 278-286.

@article{f930f711424040f68724b1cbfdb5015f,

title = "Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes",

keywords = "Cardiac inotropy, Ca2+ handling, NCX inhibition, ORM-10962, SODIUM-CALCIUM EXCHANGE, NA+/CA2+ EXCHANGER, NA+-CA2+ EXCHANGE, CA2+ CURRENT, SARCOPLASMIC-RETICULUM, HEART-FAILURE, TRANSPORT, CONTRACTILITY, KB-R7943, RELEASE",

author = "Kinga Oravecz and Anita Kormos and Andrea Gruber and Zoltan Marton and Zsofia Kohajda and Leila Mirzaei and Norbert Jost and Jouko Levijoki and Piero Pollesello and Tuula Koskelainen and Leena Otsomaa and Andras Toth and Papp, {Julius Gy.} and Nanasi, {Peter P.} and Gudrun Antoons and Andras Varro and Karoly Acsai and Norbert Nagy",

year = "2018",

month = jan,

day = "5",

doi = "10.1016/j.ejphar.2017.10.039",

language = "English",

volume = "818",

pages = "278--286",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier Science",

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Oravecz, K, Kormos, A, Gruber, A, Marton, Z, Kohajda, Z, Mirzaei, L, Jost, N, Levijoki, J, Pollesello, P, Koskelainen, T, Otsomaa, L, Toth, A, Papp, JG, Nanasi, PP, Antoons, G, Varro, A, Acsai, K & Nagy, N 2018, 'Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes', European Journal of Pharmacology, vol. 818, pp. 278-286. https://doi.org/10.1016/j.ejphar.2017.10.039

Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. / Oravecz, Kinga; Kormos, Anita; Gruber, Andrea; Marton, Zoltan; Kohajda, Zsofia; Mirzaei, Leila; Jost, Norbert; Levijoki, Jouko; Pollesello, Piero; Koskelainen, Tuula; Otsomaa, Leena; Toth, Andras; Papp, Julius Gy.; Nanasi, Peter P.; Antoons, Gudrun; Varro, Andras; Acsai, Karoly; Nagy, Norbert.

In: European Journal of Pharmacology, Vol. 818, 05.01.2018, p. 278-286.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes

AU - Oravecz, Kinga

AU - Kormos, Anita

AU - Gruber, Andrea

AU - Marton, Zoltan

AU - Kohajda, Zsofia

AU - Mirzaei, Leila

AU - Jost, Norbert

AU - Levijoki, Jouko

AU - Pollesello, Piero

AU - Koskelainen, Tuula

AU - Otsomaa, Leena

AU - Toth, Andras

AU - Papp, Julius Gy.

AU - Nanasi, Peter P.

AU - Antoons, Gudrun

AU - Varro, Andras

AU - Acsai, Karoly

AU - Nagy, Norbert

PY - 2018/1/5

Y1 - 2018/1/5

KW - Cardiac inotropy

KW - Ca2+ handling

KW - NCX inhibition

KW - ORM-10962

KW - SODIUM-CALCIUM EXCHANGE

KW - NA+/CA2+ EXCHANGER

KW - NA+-CA2+ EXCHANGE

KW - CA2+ CURRENT

KW - SARCOPLASMIC-RETICULUM

KW - HEART-FAILURE

KW - TRANSPORT

KW - CONTRACTILITY

KW - KB-R7943

KW - RELEASE

U2 - 10.1016/j.ejphar.2017.10.039

DO - 10.1016/j.ejphar.2017.10.039

M3 - Article

C2 - 29066415

VL - 818

SP - 278

EP - 286

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

ER -