Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes

Kinga Oravecz, Anita Kormos, Andrea Gruber, Zoltan Marton, Zsofia Kohajda, Leila Mirzaei, Norbert Jost, Jouko Levijoki, Piero Pollesello, Tuula Koskelainen, Leena Otsomaa, Andras Toth, Julius Gy. Papp, Peter P. Nanasi, Gudrun Antoons, Andras Varro, Karoly Acsai, Norbert Nagy

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)278-286
Number of pages9
JournalEuropean Journal of Pharmacology
Volume818
DOIs
Publication statusPublished - 5 Jan 2018

Keywords

  • Cardiac inotropy
  • Ca2+ handling
  • NCX inhibition
  • ORM-10962
  • SODIUM-CALCIUM EXCHANGE
  • NA+/CA2+ EXCHANGER
  • NA+-CA2+ EXCHANGE
  • CA2+ CURRENT
  • SARCOPLASMIC-RETICULUM
  • HEART-FAILURE
  • TRANSPORT
  • CONTRACTILITY
  • KB-R7943
  • RELEASE

Cite this