Innovative assays to detect bleeding and thrombotic tendencies: a focus on thrombin generation and fibrin formation

L.P.J. Pelkmans

Research output: ThesisDoctoral ThesisInternal

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Currently, Pelkmans is developing a new test allowing the detection of bleeding and thrombosis tendencies by measuring thrombin generation as well as fibrin formation. An important characteristic of this new test is measurements being carried out under flow conditions, whereas current tests measure under (almost) static conditions. As a result of the test measuring under blood flow conditions, a more factual approach to the human body is used. In addition, the number of laboratory tests is reduced as two parameters usually tested separately are now measured simultaneously.

Pelkmans also studied tests used to indicate the presence of the antiphospholipid syndrome (APS), which is characterised by thrombosis and/or pregnancy complications. The presence of this syndrome is indicated by using laboratory tests which are not always accurate methods for diagnosis of this syndrome. Therefore, she initiated the development of a new test aimed at improving the diagnosis and treatment of APS.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Heemskerk, Johan, Supervisor
  • Hemker, H.C., Supervisor, External person
  • de Laat, B., Co-Supervisor, External person
  • Kelchtermans, H., Co-Supervisor, External person
Award date12 Nov 2015
Place of Publication‘s-Hertogenbosch
Print ISBNs9789462952904
Publication statusPublished - 2015


  • thrombosis
  • fibrin
  • tests
  • APS

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