TY - JOUR
T1 - Initial weight loss on an 800-kcal diet as a predictor of weight loss success after 8 weeks: the Diogenes study.
AU - Handjieva Darlenska, T.
AU - Handjiev, S.
AU - Larsen, T.M.
AU - van Baak, M.A.
AU - Jebb, S.
AU - Papadaki, A.
AU - Pfeiffer, A.F.
AU - Martinez, J.A.
AU - Kunesova, M.
AU - Holst, C.
AU - Saris, W.H.M.
AU - Astrup, A.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Objective:The purpose of this study was to investigate whether pre-treatment subject characteristics and weight change during the first weeks of a low-calorie diet (LCD) can predict weight loss outcomes at the end of a controlled 8-week weight loss period in overweight and obese adults.Subjects:A total of 932 overweight and obese subjects of both genders were included at eight European centers, and underwent an 8-week LCD period.Results:The weight loss at week 8 was positively correlated with initial body weight (Spearman's rho=0.62), height (rho=0.43), body mass index (rho=0.43), waist (rho=0.48) and hip circumference (rho=0.33), sagittal diameter (rho=0.45), fat mass (rho=0.35) and fat-free mass (rho=0.52), and gender (rho=-0.36) (all P<0.01). In the multivariate regression model, adjusted for center, only initial body weight, early weight loss (week 1) and weight loss at week 3 were significant predictors of weight loss outcome at week 8: weight loss (kg) at week 8=0.09+0.046 x baseline body weight (kg)-0.311 x weight loss (kg) at week 1+1.284 x weight loss (kg) at week 3 (R (2)=68%, P<0.0001). A weight loss of >/=2.6 kg at week 1 during the LCD period was identified as the optimal cut-off predictor for at least 10 kg weight loss at week 8.Conclusions:This study suggests that initial body weight, early weight loss (week 1) and weight loss at week 3 are predictors of final weight loss during an 8-week LCD, and may be used as early biomarkers of subsequent responses to an LCD diet.European Journal of Clinical Nutrition advance online publication, 30 June 2010; doi:10.1038/ejcn.2010.110.
AB - Objective:The purpose of this study was to investigate whether pre-treatment subject characteristics and weight change during the first weeks of a low-calorie diet (LCD) can predict weight loss outcomes at the end of a controlled 8-week weight loss period in overweight and obese adults.Subjects:A total of 932 overweight and obese subjects of both genders were included at eight European centers, and underwent an 8-week LCD period.Results:The weight loss at week 8 was positively correlated with initial body weight (Spearman's rho=0.62), height (rho=0.43), body mass index (rho=0.43), waist (rho=0.48) and hip circumference (rho=0.33), sagittal diameter (rho=0.45), fat mass (rho=0.35) and fat-free mass (rho=0.52), and gender (rho=-0.36) (all P<0.01). In the multivariate regression model, adjusted for center, only initial body weight, early weight loss (week 1) and weight loss at week 3 were significant predictors of weight loss outcome at week 8: weight loss (kg) at week 8=0.09+0.046 x baseline body weight (kg)-0.311 x weight loss (kg) at week 1+1.284 x weight loss (kg) at week 3 (R (2)=68%, P<0.0001). A weight loss of >/=2.6 kg at week 1 during the LCD period was identified as the optimal cut-off predictor for at least 10 kg weight loss at week 8.Conclusions:This study suggests that initial body weight, early weight loss (week 1) and weight loss at week 3 are predictors of final weight loss during an 8-week LCD, and may be used as early biomarkers of subsequent responses to an LCD diet.European Journal of Clinical Nutrition advance online publication, 30 June 2010; doi:10.1038/ejcn.2010.110.
U2 - 10.1038/ejcn.2010.110
DO - 10.1038/ejcn.2010.110
M3 - Article
C2 - 20588292
SN - 0954-3007
VL - 64
SP - 994
EP - 999
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 9
ER -