Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept

Benedikt Linz, Arnela Saljic, Mathias Hohl, Monika Gawalko, Thomas Jespersen, Prashanthan Sanders, Michael Bohm, Dominik Linz*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

4 Citations (Web of Science)

Abstract

Arterial hypertension is one of the main contributors to cardiovascular diseases, including stroke, heart failure, and coronary heart disease. Salt plays a major role in the regulation of blood pressure and is one of the most critical factors for hypertension and stroke. At the individual level, effective salt reduction is difficult to achieve and available methods for managing sodium balance are lacking for many patients. As part of the ingested food, salt is absorbed in the gastrointestinal tract by the sodium proton exchanger subtype 3 (NHE3 also known as Slc9a3), influencing extracellular fluid volume and blood pressure.

In this review, we discuss the beneficial effects of pharmacological inhibition of NHE3-mediated sodium absorption in the gut and focus on the effect on blood pressure and end-organ damage. (C) 2020 Published by Elsevier B.V.

Original languageEnglish
Article number100591
Number of pages7
JournalIJC Heart & Vasculature
Volume29
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Hypertension
  • Blood pressure
  • Salt
  • Sodium-proton-exchanger
  • Gut
  • IRRITABLE-BOWEL-SYNDROME
  • BLOOD-PRESSURE
  • HUMAN MICROBIOME
  • NHE3 EXPRESSION
  • DIETARY-SODIUM
  • SALT INTAKE
  • TENAPANOR
  • KIDNEY
  • WATER
  • HYPERTENSION

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