Inhibition of pre-supplementary motor area by continuous theta burst stimulation leads to more cautious decision-making and more efficient sensory evidence integration

Tuğçe Tosun, Dilara Berkay, Alexander T. Sack, Yusuf Ö Çakmak, Fuat Balcı

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Decisions are made based on the integration of available evidence. The noise in evidence accumulation leads to a particular speed-accuracy tradeoff in decision-making, which can be modulated and optimized by adaptive decision threshold setting. Given the effect of pre-SMA activity on striatal excitability, we hypothesized that the inhibition of pre-SMA would lead to higher decision thresholds and an increased accuracy bias. We used offline continuous theta burst stimulation to assess the effect of transient inhibition of the right pre-SMA on the decision processes in a free-response two-alternative forced-choice task within the drift diffusion model framework. Participants became more cautious and set higher decision thresholds following right pre-SMA inhibition compared with inhibition of the control site (vertex). Increased decision thresholds were accompanied by an accuracy bias with no effects on post-error choice behavior. Participants also exhibited higher drift rates as a result of pre-SMA inhibition compared with the vertex inhibition. These results, in line with the striatal theory of speed-accuracy tradeoff, provide evidence for the functional role of pre-SMA activity in decision threshold modulation. Our results also suggest that pre-SMA might be a part of the brain network associated with the sensory evidence integration.

Original languageEnglish
Pages (from-to)1433-1444
Number of pages12
JournalJournal of Cognitive Neuroscience
Volume29
Issue number8
Early online date7 Apr 2017
DOIs
Publication statusPublished - Aug 2017

Keywords

  • SPEED-ACCURACY TRADEOFF
  • DIFFUSION-MODEL ANALYSIS
  • PERCEPTUAL DECISION
  • BASAL GANGLIA
  • SUBTHALAMIC NUCLEUS
  • NEURAL BASIS
  • HUMAN BRAIN
  • CORTEX
  • TASK
  • THRESHOLD

Cite this