Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction

Ward A. Heggermont, Anna-Pia Papageorgiou, Annelies Quaegebeur, Sophie Deckx, Paolo Carai, Wouter Verhesen, Guy Eelen, Sandra Schoors, Rick van Leeuwen, Sergey Alekseev, Ies Elzenaar, Stefan Vinckier, Peter Pokreisz, Ann-Sophie Walravens, Rik Gijsbers, Chris Van Den Haute, Alexander Nickel, Blanche Schroen, Marc van Bilsen, Stefan JanssensChristoph Maack, Yigal Pinto, Peter Carmeliet, Stephane Heymans*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)747-761
Number of pages33
JournalCirculation
Volume136
Issue number8
DOIs
Publication statusPublished - 22 Aug 2017

Keywords

  • cardiac dysfunction
  • heart failure
  • metabolic remodeling
  • microRNA
  • KETOGLUTARATE DEHYDROGENASE COMPLEX
  • PRESERVED EJECTION FRACTION
  • HEART-FAILURE
  • ENDOTHELIAL DYSFUNCTION
  • HUMAN-DISEASE
  • METABOLISM
  • DICHLOROACETATE
  • GLYCOLYSIS
  • OXIDATION
  • RESPONSES

Cite this

Heggermont, W. A., Papageorgiou, A-P., Quaegebeur, A., Deckx, S., Carai, P., Verhesen, W., Eelen, G., Schoors, S., van Leeuwen, R., Alekseev, S., Elzenaar, I., Vinckier, S., Pokreisz, P., Walravens, A-S., Gijsbers, R., Van Den Haute, C., Nickel, A., Schroen, B., van Bilsen, M., ... Heymans, S. (2017). Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. Circulation, 136(8), 747-761. https://doi.org/10.1161/CIRCULATIONAHA.116.024171