Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice

Olga C. Jorge-Torres, Karolina Szczesna, Laura Roa, Carme Casal, Louisa Gonzalez-Somermeyer, Marta Soler, Cecilia D. Velasco, Pablo Martinez-San Segundo, Paolo Petazzi, Mauricio A. Saez, Raul Delgado-Morales, Stephane Fourcade, Aurora Pujol, Dori Huertas, Artur Llobet, Sonia Guil, Manel Esteller

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1665-1677
Number of pages13
JournalCell Reports
Volume23
Issue number6
DOIs
Publication statusPublished - 8 May 2018

Keywords

  • GLYCOGEN-SYNTHASE KINASE-3
  • LONG-TERM POTENTIATION
  • ALZHEIMERS-DISEASE
  • MOUSE MODEL
  • TYROSINE PHOSPHORYLATION
  • PROTEIN-SYNTHESIS
  • INACTIVATION
  • MECP2
  • GSK3-BETA
  • NEURONS

Cite this

Jorge-Torres, O. C., Szczesna, K., Roa, L., Casal, C., Gonzalez-Somermeyer, L., Soler, M., Velasco, C. D., Segundo, P. M-S., Petazzi, P., Saez, M. A., Delgado-Morales, R., Fourcade, S., Pujol, A., Huertas, D., Llobet, A., Guil, S., & Esteller, M. (2018). Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice. Cell Reports, 23(6), 1665-1677. https://doi.org/10.1016/j.celrep.2018.04.010