Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice

Olga C. Jorge-Torres; Karolina Szczesna; Laura Roa; Carme Casal; Louisa Gonzalez-Somermeyer; Marta Soler; Cecilia D. Velasco; Pablo Martinez-San Segundo; Paolo Petazzi; Mauricio A. Saez; Raul Delgado-Morales; Stephane Fourcade; Aurora Pujol; Dori Huertas; Artur Llobet; Sonia Guil; Manel Esteller

doi:10.1016/j.celrep.2018.04.010

Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice

Olga C. Jorge-Torres, Karolina Szczesna, Laura Roa, Carme Casal, Louisa Gonzalez-Somermeyer, Marta Soler, Cecilia D. Velasco, Pablo Martinez-San Segundo, Paolo Petazzi, Mauricio A. Saez, Raul Delgado-Morales, Stephane Fourcade, Aurora Pujol, Dori Huertas, Artur Llobet, Sonia Guil, Manel Esteller

MHeNs - Neuroscience

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1665-1677
Number of pages	13
Journal	Cell Reports
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2018.04.010
Publication status	Published - 8 May 2018

Keywords

GLYCOGEN-SYNTHASE KINASE-3
LONG-TERM POTENTIATION
ALZHEIMERS-DISEASE
MOUSE MODEL
TYROSINE PHOSPHORYLATION
PROTEIN-SYNTHESIS
INACTIVATION
MECP2
GSK3-BETA
NEURONS

Access to Document

10.1016/j.celrep.2018.04.010

Cite this

Jorge-Torres, O. C., Szczesna, K., Roa, L., Casal, C., Gonzalez-Somermeyer, L., Soler, M., Velasco, C. D., Segundo, P. M-S., Petazzi, P., Saez, M. A., Delgado-Morales, R., Fourcade, S., Pujol, A., Huertas, D., Llobet, A., Guil, S., & Esteller, M. (2018). Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice. Cell Reports, 23(6), 1665-1677. https://doi.org/10.1016/j.celrep.2018.04.010

Jorge-Torres, Olga C. ; Szczesna, Karolina ; Roa, Laura ; Casal, Carme ; Gonzalez-Somermeyer, Louisa ; Soler, Marta ; Velasco, Cecilia D. ; Segundo, Pablo Martinez-San ; Petazzi, Paolo ; Saez, Mauricio A. ; Delgado-Morales, Raul ; Fourcade, Stephane ; Pujol, Aurora ; Huertas, Dori ; Llobet, Artur ; Guil, Sonia ; Esteller, Manel. / Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice. In: Cell Reports. 2018 ; Vol. 23, No. 6. pp. 1665-1677.

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title = "Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice",

keywords = "GLYCOGEN-SYNTHASE KINASE-3, LONG-TERM POTENTIATION, ALZHEIMERS-DISEASE, MOUSE MODEL, TYROSINE PHOSPHORYLATION, PROTEIN-SYNTHESIS, INACTIVATION, MECP2, GSK3-BETA, NEURONS",

author = "Jorge-Torres, {Olga C.} and Karolina Szczesna and Laura Roa and Carme Casal and Louisa Gonzalez-Somermeyer and Marta Soler and Velasco, {Cecilia D.} and Segundo, {Pablo Martinez-San} and Paolo Petazzi and Saez, {Mauricio A.} and Raul Delgado-Morales and Stephane Fourcade and Aurora Pujol and Dori Huertas and Artur Llobet and Sonia Guil and Manel Esteller",

year = "2018",

month = may,

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doi = "10.1016/j.celrep.2018.04.010",

language = "English",

volume = "23",

pages = "1665--1677",

journal = "Cell Reports",

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Jorge-Torres, OC, Szczesna, K, Roa, L, Casal, C, Gonzalez-Somermeyer, L, Soler, M, Velasco, CD, Segundo, PM-S, Petazzi, P, Saez, MA, Delgado-Morales, R, Fourcade, S, Pujol, A, Huertas, D, Llobet, A, Guil, S & Esteller, M 2018, 'Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice', Cell Reports, vol. 23, no. 6, pp. 1665-1677. https://doi.org/10.1016/j.celrep.2018.04.010

Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice. / Jorge-Torres, Olga C.; Szczesna, Karolina; Roa, Laura; Casal, Carme; Gonzalez-Somermeyer, Louisa; Soler, Marta; Velasco, Cecilia D.; Segundo, Pablo Martinez-San; Petazzi, Paolo; Saez, Mauricio A.; Delgado-Morales, Raul; Fourcade, Stephane; Pujol, Aurora; Huertas, Dori; Llobet, Artur; Guil, Sonia; Esteller, Manel.

In: Cell Reports, Vol. 23, No. 6, 08.05.2018, p. 1665-1677.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice

AU - Jorge-Torres, Olga C.

AU - Szczesna, Karolina

AU - Roa, Laura

AU - Casal, Carme

AU - Gonzalez-Somermeyer, Louisa

AU - Soler, Marta

AU - Velasco, Cecilia D.

AU - Segundo, Pablo Martinez-San

AU - Petazzi, Paolo

AU - Saez, Mauricio A.

AU - Delgado-Morales, Raul

AU - Fourcade, Stephane

AU - Pujol, Aurora

AU - Huertas, Dori

AU - Llobet, Artur

AU - Guil, Sonia

AU - Esteller, Manel

PY - 2018/5/8

Y1 - 2018/5/8

KW - GLYCOGEN-SYNTHASE KINASE-3

KW - LONG-TERM POTENTIATION

KW - ALZHEIMERS-DISEASE

KW - MOUSE MODEL

KW - TYROSINE PHOSPHORYLATION

KW - PROTEIN-SYNTHESIS

KW - INACTIVATION

KW - MECP2

KW - GSK3-BETA

KW - NEURONS

U2 - 10.1016/j.celrep.2018.04.010

DO - 10.1016/j.celrep.2018.04.010

M3 - Article

C2 - 29742424

VL - 23

SP - 1665

EP - 1677

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 6

ER -