Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice

Tulasi Yadati, Tom Houben, Albert Bitorina, Yvonne Oligschlaeger, Marion J Gijbels, Ronny Mohren, Dieter Lütjohann, Princy Khurana, Sandeep Goyal, Aditya Kulkarni, Jan Theys, Berta Cillero-Pastor, Ronit Shiri-Sverdlov

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number675535
Number of pages13
JournalFrontiers in Immunology
Volume12
DOIs
Publication statusPublished - 16 Jul 2021

Keywords

  • NASH
  • lysosomal enzymes
  • lipoprotein metabolism
  • inflammation
  • extracellular cathepsin D
  • small-compound inhibitors
  • NONALCOHOLIC STEATOHEPATITIS
  • LYSOSOMAL-ENZYMES
  • ATHEROSCLEROSIS
  • BIOSYNTHESIS
  • PREVALENCE
  • HYDROLASES
  • PROTEASES
  • TISSUE
  • SERUM

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