Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Suzanne A. B. M. Aarts; Tom T. P. Seijkens; Pascal J. H. Kusters; Susanne M. A. van der Pol; Barbara Zarzycka; Priscilla D. A. M. Heijnen; Linda Beckers; Myrthe den Toom; Marion J. J. Gijbels; Louis Boon; Christian Weber; Helga E. de Vries; Gerry A. F. Nicolaes; Christine D. Dijkstra; Gijs Kooij; Esther Lutgens

doi:10.1186/s12974-017-0875-9

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	105
Number of pages	14
Journal	Journal of Neuroinflammation
Volume	14
DOIs	https://doi.org/10.1186/s12974-017-0875-9
Publication status	Published - 12 May 2017

Keywords

Multiple sclerosis
EAE
Co-stimulation
Monocytes
Inflammation
BLOOD-BRAIN-BARRIER
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
MULTIPLE-SCLEROSIS PATHOGENESIS
ANTI-CD40 MONOCLONAL-ANTIBODY
CENTRAL-NERVOUS-SYSTEM
DEMYELINATING DISEASE
DOUBLE-BLIND
MOUSE MODEL
IN-VITRO
PHASE-I

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10.1186/s12974-017-0875-9

Cite this

Aarts, S. A. B. M., Seijkens, T. T. P., Kusters, P. J. H., van der Pol, S. M. A., Zarzycka, B., Heijnen, P. D. A. M., Beckers, L., den Toom, M., Gijbels, M. J. J., Boon, L., Weber, C., de Vries, H. E., Nicolaes, G. A. F., Dijkstra, C. D., Kooij, G., & Lutgens, E. (2017). Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation. Journal of Neuroinflammation, 14, [105]. https://doi.org/10.1186/s12974-017-0875-9

Aarts, Suzanne A. B. M. ; Seijkens, Tom T. P. ; Kusters, Pascal J. H. ; van der Pol, Susanne M. A. ; Zarzycka, Barbara ; Heijnen, Priscilla D. A. M. ; Beckers, Linda ; den Toom, Myrthe ; Gijbels, Marion J. J. ; Boon, Louis ; Weber, Christian ; de Vries, Helga E. ; Nicolaes, Gerry A. F. ; Dijkstra, Christine D. ; Kooij, Gijs ; Lutgens, Esther. / Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation. In: Journal of Neuroinflammation. 2017 ; Vol. 14.

@article{605f7d4445b94ff49c1194e76b06b222,

title = "Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation",

keywords = "Multiple sclerosis, EAE, Co-stimulation, Monocytes, Inflammation, BLOOD-BRAIN-BARRIER, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, MULTIPLE-SCLEROSIS PATHOGENESIS, ANTI-CD40 MONOCLONAL-ANTIBODY, CENTRAL-NERVOUS-SYSTEM, DEMYELINATING DISEASE, DOUBLE-BLIND, MOUSE MODEL, IN-VITRO, PHASE-I",

author = "Aarts, {Suzanne A. B. M.} and Seijkens, {Tom T. P.} and Kusters, {Pascal J. H.} and {van der Pol}, {Susanne M. A.} and Barbara Zarzycka and Heijnen, {Priscilla D. A. M.} and Linda Beckers and {den Toom}, Myrthe and Gijbels, {Marion J. J.} and Louis Boon and Christian Weber and {de Vries}, {Helga E.} and Nicolaes, {Gerry A. F.} and Dijkstra, {Christine D.} and Gijs Kooij and Esther Lutgens",

year = "2017",

month = may,

day = "12",

doi = "10.1186/s12974-017-0875-9",

language = "English",

volume = "14",

journal = "Journal of Neuroinflammation",

issn = "1742-2094",

publisher = "BioMed Central Ltd",

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Aarts, SABM, Seijkens, TTP, Kusters, PJH, van der Pol, SMA, Zarzycka, B, Heijnen, PDAM, Beckers, L, den Toom, M, Gijbels, MJJ , Boon, L , Weber, C, de Vries, HE, Nicolaes, GAF, Dijkstra, CD, Kooij, G & Lutgens, E 2017, 'Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation', Journal of Neuroinflammation, vol. 14, 105. https://doi.org/10.1186/s12974-017-0875-9

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation. / Aarts, Suzanne A. B. M.; Seijkens, Tom T. P.; Kusters, Pascal J. H.; van der Pol, Susanne M. A.; Zarzycka, Barbara; Heijnen, Priscilla D. A. M.; Beckers, Linda; den Toom, Myrthe; Gijbels, Marion J. J.; Boon, Louis ; Weber, Christian; de Vries, Helga E.; Nicolaes, Gerry A. F.; Dijkstra, Christine D.; Kooij, Gijs; Lutgens, Esther.

In: Journal of Neuroinflammation, Vol. 14, 105, 12.05.2017.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

AU - Aarts, Suzanne A. B. M.

AU - Seijkens, Tom T. P.

AU - Kusters, Pascal J. H.

AU - van der Pol, Susanne M. A.

AU - Zarzycka, Barbara

AU - Heijnen, Priscilla D. A. M.

AU - Beckers, Linda

AU - den Toom, Myrthe

AU - Gijbels, Marion J. J.

AU - Boon, Louis

AU - Weber, Christian

AU - de Vries, Helga E.

AU - Nicolaes, Gerry A. F.

AU - Dijkstra, Christine D.

AU - Kooij, Gijs

AU - Lutgens, Esther

PY - 2017/5/12

Y1 - 2017/5/12

KW - Multiple sclerosis

KW - EAE

KW - Co-stimulation

KW - Monocytes

KW - Inflammation

KW - BLOOD-BRAIN-BARRIER

KW - EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

KW - MULTIPLE-SCLEROSIS PATHOGENESIS

KW - ANTI-CD40 MONOCLONAL-ANTIBODY

KW - CENTRAL-NERVOUS-SYSTEM

KW - DEMYELINATING DISEASE

KW - DOUBLE-BLIND

KW - MOUSE MODEL

KW - IN-VITRO

KW - PHASE-I

U2 - 10.1186/s12974-017-0875-9

DO - 10.1186/s12974-017-0875-9

M3 - Article

VL - 14

JO - Journal of Neuroinflammation

JF - Journal of Neuroinflammation

SN - 1742-2094

M1 - 105

ER -