Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number105
Number of pages14
JournalJournal of Neuroinflammation
Volume14
DOIs
Publication statusPublished - 12 May 2017

Keywords

  • Multiple sclerosis
  • EAE
  • Co-stimulation
  • Monocytes
  • Inflammation
  • BLOOD-BRAIN-BARRIER
  • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
  • MULTIPLE-SCLEROSIS PATHOGENESIS
  • ANTI-CD40 MONOCLONAL-ANTIBODY
  • CENTRAL-NERVOUS-SYSTEM
  • DEMYELINATING DISEASE
  • DOUBLE-BLIND
  • MOUSE MODEL
  • IN-VITRO
  • PHASE-I

Cite this

Aarts, S. A. B. M., Seijkens, T. T. P., Kusters, P. J. H., van der Pol, S. M. A., Zarzycka, B., Heijnen, P. D. A. M., Beckers, L., den Toom, M., Gijbels, M. J. J., Boon, L., Weber, C., de Vries, H. E., Nicolaes, G. A. F., Dijkstra, C. D., Kooij, G., & Lutgens, E. (2017). Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation. Journal of Neuroinflammation, 14, [105]. https://doi.org/10.1186/s12974-017-0875-9