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Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo
Yaw Asare
, Miriam Ommer
, Florence. A. Azombo
, Setareh Alampour-Rajabi
, Marieke Sternkopf
, Maryam Sanati
,
Marion J. Gijbels
, Corinna Schmitz
, Dzmitry Sinitski
, Pathricia V. Tilstam
, Hongqi Lue
, Andre Gessner
, Denise Lange
, Johannes A. Schmid
,
Christian Weber
, Martin Dichgans
,
Joachim Jankowski
, Ruggero Pardi
, Menno P. J. de Winther
,
Heidi Noels
*
Juergen Bernhagen
*
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*
Corresponding author for this work
Pathologie
Biochemie
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Dive into the research topics of 'Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo'. Together they form a unique fingerprint.
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Keyphrases
Atherogenesis
100%
Signalosome
100%
MLN4924
100%
Photomorphogenesis
100%
COP9 Signalosome
80%
Hypoxia-inducible factor-1α (HIF-1α)
40%
Macrophages
40%
Nuclear factor-κB
40%
Atherosclerotic Lesions
40%
A-level
40%
NF-κB Signaling
40%
Inflammatory Cytokine Response
20%
Endothelium
20%
Chemokines
20%
Monocytes
20%
Net Effect
20%
Aorta
20%
LPS-induced Inflammation
20%
Endothelial Cells
20%
Aortic Root
20%
ApoE KO Mice
20%
Macrophage Phenotype
20%
Genomic Deletion
20%
Inflammatory Gene Expression
20%
Male Mice
20%
Neutrophil Count
20%
Adhesion Molecules
20%
Atherosclerotic Artery
20%
Arginase-1 (Arg-1)
20%
Advanced Lesions
20%
Monocyte Count
20%
Isopeptidase
20%
Deneddylation
20%
Neural Precursor Cell Expressed
20%
Cullin
20%
Neddylation
20%
Lesion Formation
20%
Atheroprotective Effects
20%
Cullin-RING E3 Ligase
20%
INIS
mice
100%
inhibition
100%
in vivo
100%
macrophages
75%
levels
50%
monocytes
50%
inflammation
50%
data
25%
neutrophils
25%
arteries
25%
humans
25%
females
25%
blood
25%
males
25%
genes
25%
phenotype
25%
cytokines
25%
endothelium
25%
precursor
25%
molecules
25%
genetics
25%
in vitro
25%
roots
25%
atherosclerosis
25%
adhesion
25%
rings
25%
aorta
25%
ligases
25%
arginase
25%
Immunology and Microbiology
Immunoglobulin Enhancer Binding Protein
100%
Photomorphogenesis
100%
Macrophage
75%
Gene Expression
25%
Proinflammatory Cytokine
25%
Myeloid
25%
Atherosclerosis
25%
Artery
25%
Precursor
25%
Chemokine
25%
Neutrophil Count
25%
Apolipoprotein E Knockout Mouse
25%
Gene Deletion
25%
Aortic Root
25%
Monocyte Count
25%
Neddylation
25%
Cell Adhesion Proteins
25%
Pharmacology, Toxicology and Pharmaceutical Science
Atherogenesis
100%
COP9 Signalosome
100%
Pevonedistat
71%
Immunoglobulin Enhancer Binding Protein
57%
Cullin
28%
Cytokine
14%
Atherosclerosis
14%
Arginase 1
14%
Apolipoprotein E Knockout Mouse
14%
Chemokine
14%
Ligase
14%
Lipopolysaccharide-Induced Inflammation
14%
Cell Adhesion Proteins
14%
Biochemistry, Genetics and Molecular Biology
COP9 Signalosome
100%
Immunoglobulin Enhancer Binding Protein
57%
Macrophage
42%
Cullin
28%
Precursor
14%
Gene Expression
14%
Myeloid
14%
Proinflammatory Cytokine
14%
Arginase
14%
Chemokine
14%
Apolipoprotein E Knockout Mouse
14%
Gene Deletion
14%
Cell Adhesion Proteins
14%
Neutrophil Count
14%
Neddylation
14%
Monocyte Count
14%
Ubiquitin Ligase
14%