Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue

J.A. van de Woerd-de Lange, M.C.E. van Dam-Mieras, H.C. Hemker

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    Abstract

    A series of 53 organic chemicals belonging to the groups of organic phosphates, sulfonyl derivatives and carbamates were screened for their activity against the coagulation factors IIa (thrombin), VIIa, IXa and Xa. Relatively specific inhibitors for the factors IIa, VIIa and Xa were found.
    Original languageEnglish
    Pages (from-to)315-347
    Number of pages33
    JournalHaemostasis
    Volume10
    Issue number6
    DOIs
    Publication statusPublished - 1981

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