Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue

J.A. van de Woerd-de Lange; M.C.E. van Dam-Mieras; H.C. Hemker

doi:10.1159/000214417

Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue

J.A. van de Woerd-de Lange, M.C.E. van Dam-Mieras, H.C. Hemker

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Abstract

A series of 53 organic chemicals belonging to the groups of organic phosphates, sulfonyl derivatives and carbamates were screened for their activity against the coagulation factors IIa (thrombin), VIIa, IXa and Xa. Relatively specific inhibitors for the factors IIa, VIIa and Xa were found.

Original language	English
Pages (from-to)	315-347
Number of pages	33
Journal	Haemostasis
Volume	10
Issue number	6
DOIs	https://doi.org/10.1159/000214417
Publication status	Published - 1981

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title = "Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue",

abstract = "A series of 53 organic chemicals belonging to the groups of organic phosphates, sulfonyl derivatives and carbamates were screened for their activity against the coagulation factors IIa (thrombin), VIIa, IXa and Xa. Relatively specific inhibitors for the factors IIa, VIIa and Xa were found.",

author = "{van de Woerd-de Lange}, J.A. and {van Dam-Mieras}, M.C.E. and H.C. Hemker",

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AU - van de Woerd-de Lange, J.A.

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AU - Hemker, H.C.

PY - 1981

Y1 - 1981

N2 - A series of 53 organic chemicals belonging to the groups of organic phosphates, sulfonyl derivatives and carbamates were screened for their activity against the coagulation factors IIa (thrombin), VIIa, IXa and Xa. Relatively specific inhibitors for the factors IIa, VIIa and Xa were found.

AB - A series of 53 organic chemicals belonging to the groups of organic phosphates, sulfonyl derivatives and carbamates were screened for their activity against the coagulation factors IIa (thrombin), VIIa, IXa and Xa. Relatively specific inhibitors for the factors IIa, VIIa and Xa were found.

U2 - 10.1159/000214417

DO - 10.1159/000214417

M3 - Article

SN - 0301-0147

VL - 10

SP - 315

EP - 347

JO - Haemostasis

JF - Haemostasis

IS - 6

ER -

Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue

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