Ingestion of an ample amount of meat substitute based on a lysine-enriched, plant-based protein blend stimulates postprandial muscle protein synthesis to a similar extent as an isonitrogenous amount of chicken in healthy, young men

Plant-based proteins are considered to be less effective in their capacity to stimulate muscle protein synthesis when compared with animal-based protein sources, likely due to differences in amino acid contents. We compared the postprandial muscle protein synthetic response following the ingestion of a lysine-enriched plant-based protein product with an isonitrogenous amount of chicken. Twenty-four men (age 24 +/- 5 years; BMI 22 center dot 9 +/- 2 center dot 6 kg center dot m(-2)) participated in this parallel, double-blind, randomised controlled trial and consumed 40 g of protein as a lysine-enriched wheat and chickpea protein product (Plant, n 12) or chicken breast fillet (Chicken, n 12). Primed, continuous intravenous l-(ring-C-13(6))-phenylalanine infusions were applied while repeated blood and muscle samples were collected over a 5-h postprandial period to assess plasma amino acid responses, muscle protein synthesis rates and muscle anabolic signalling responses. Postprandial plasma leucine and essential amino acid concentrations were higher following Chicken (P < 0 center dot 001), while plasma lysine concentrations were higher throughout in Plant (P < 0 center dot 001). Total plasma amino acid concentrations did not differ between interventions (P = 0 center dot 181). Ingestion of both Plant and Chicken increased muscle protein synthesis rates from post-absorptive: 0 center dot 031 +/- 0 center dot 011 and 0 center dot 031 +/- 0 center dot 013 to postprandial: 0 center dot 046 +/- 0 center dot 010 and 0 center dot 055 +/- 0 center dot 015 % h(-1), respectively (P-time < 0 center dot 001), with no differences between Plant and Chicken (time x treatment P = 0 center dot 068). Ingestion of 40 g of protein in the form of a lysine-enriched plant-based protein product increases muscle protein synthesis rates to a similar extent as an isonitrogenous amount of chicken in healthy, young men. Plant-based protein products sold as meat replacers may be as effective as animal-based protein sources to stimulate postprandial muscle protein synthesis rates in healthy, young individuals.