TY - JOUR
T1 - Influence of the Urban Exposome on Birth Weight
AU - Nieuwenhuijsen, Mark J.
AU - Agier, Lydiane
AU - Basagana, Xavier
AU - Urquiza, Jose
AU - Tamayo-Uria, Ibon
AU - Giorgis-Allemand, Lise
AU - Robinson, Oliver
AU - Siroux, Valerie
AU - Maitre, Lea
AU - de Castro, Montserrat
AU - Valentin, Antonia
AU - Donaire, David
AU - Dadvand, Payam
AU - Aasvang, Gunn Marit
AU - Krog, Norun Hjertager
AU - Schwarze, Per E.
AU - Chatzi, Leda
AU - Grazuleviciene, Regina
AU - Andrusaityte, Sandra
AU - Dedele, Audrius
AU - McEachan, Rosie
AU - Wright, John
AU - West, Jane
AU - Ibarluzea, Jesus
AU - Ballester, Ferran
AU - Vrijheid, Martine
AU - Slama, Remy
PY - 2019/4
Y1 - 2019/4
N2 - BACKGROUND: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life.OBJECTIVE: We evaluated the association of the urban exposome with birth weight.METHODS: We estimated exposure to the urban exposome, including the built environment, air pollution, road traffic noise, meteorology, natural space, and road traffic (corresponding to 24 environmental indicators and 60 exposures) for nearly 32,000 pregnant women from six European birth cohorts. To evaluate associations with either continuous birth weight or term low birth weight (TLBW) risk, we primarily relied on the Deletion-Substitution-Addition (DSA) algorithm, which is an extension of the stepwise variable selection method. Second, we used an exposure-by-exposure exposome-wide association studies (ExWAS) method accounting for multiple hypotheses testing to report associations not adjusted for coexposures.RESULTS: The most consistent statistically significant associations were observed between increasing green space exposure estimated as Normalized Difference Vegetation Index (NDVI) and increased birth weight and decreased TLBW risk. Furthermore, we observed statistically significant associations among presence of public bus line, land use Shannon's Evenness Index, and traffic density and birth weight in our DSA analysis.CONCLUSION: This investigation is the first large urban exposome study of birth weight that tests many environmental urban exposures. It confirmed previously reported associations for NDVI and generated new hypotheses for a number of built-environment exposures.
AB - BACKGROUND: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life.OBJECTIVE: We evaluated the association of the urban exposome with birth weight.METHODS: We estimated exposure to the urban exposome, including the built environment, air pollution, road traffic noise, meteorology, natural space, and road traffic (corresponding to 24 environmental indicators and 60 exposures) for nearly 32,000 pregnant women from six European birth cohorts. To evaluate associations with either continuous birth weight or term low birth weight (TLBW) risk, we primarily relied on the Deletion-Substitution-Addition (DSA) algorithm, which is an extension of the stepwise variable selection method. Second, we used an exposure-by-exposure exposome-wide association studies (ExWAS) method accounting for multiple hypotheses testing to report associations not adjusted for coexposures.RESULTS: The most consistent statistically significant associations were observed between increasing green space exposure estimated as Normalized Difference Vegetation Index (NDVI) and increased birth weight and decreased TLBW risk. Furthermore, we observed statistically significant associations among presence of public bus line, land use Shannon's Evenness Index, and traffic density and birth weight in our DSA analysis.CONCLUSION: This investigation is the first large urban exposome study of birth weight that tests many environmental urban exposures. It confirmed previously reported associations for NDVI and generated new hypotheses for a number of built-environment exposures.
KW - AMBIENT AIR-POLLUTION
KW - USE REGRESSION-MODELS
KW - COHORT PROFILE
KW - LAND-USE
KW - RESIDENTIAL GREENNESS
KW - WIDE ASSOCIATION
KW - PRETERM BIRTH
KW - CHILD COHORT
KW - HEALTH
KW - PREGNANCY
U2 - 10.1289/EHP3971
DO - 10.1289/EHP3971
M3 - Article
C2 - 31009264
VL - 127
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 4
M1 - 047007
ER -