Influence of the gut microbiota on satiety signaling

J.J.A.J. Bastings; K. Venema; E.E. Blaak; T.C. Adam

doi:10.1016/j.tem.2023.02.003

Influence of the gut microbiota on satiety signaling

J.J.A.J. Bastings, K. Venema, E.E. Blaak^*, T.C. Adam

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

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Abstract

Recent studies show a link between the gut microbiota and the regulation of satiety and energy intake, processes that contribute to the development and pathophysiol-ogy of metabolic diseases. However, this link is predominantly established in animal and in vitro studies, whereas human intervention studies are scarce. In this review we focus on recent evidence linking satiety and the gut microbiome, with specific emphasis on gut microbial short-chain fatty acids (SCFAs). Based on a systematic search we provide an overview of human studies linking the intake of prebiotics with gut microbial alterations and satiety signaling. Our outcomes highlight the importance of in-depth examination of the gut microbiota in relation to satiety and provide insights into recent and future studies in this field.

Original language	English
Pages (from-to)	243-255
Number of pages	13
Journal	Trends in Endocrinology and Metabolism
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.tem.2023.02.003
Publication status	Published - 1 Apr 2023

Keywords

CHAIN FATTY-ACIDS
GLUCAGON-LIKE PEPTIDE-1
PROTEIN-COUPLED RECEPTOR
ENTEROENDOCRINE L CELLS
WHOLE-GRAIN RYE
APPETITE REGULATION
METABOLIC SYNDROME
DIETARY FIBER
INTESTINAL BARRIER
INSULIN-SECRETION

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title = "Influence of the gut microbiota on satiety signaling",

abstract = "Recent studies show a link between the gut microbiota and the regulation of satiety and energy intake, processes that contribute to the development and pathophysiol-ogy of metabolic diseases. However, this link is predominantly established in animal and in vitro studies, whereas human intervention studies are scarce. In this review we focus on recent evidence linking satiety and the gut microbiome, with specific emphasis on gut microbial short-chain fatty acids (SCFAs). Based on a systematic search we provide an overview of human studies linking the intake of prebiotics with gut microbial alterations and satiety signaling. Our outcomes highlight the importance of in-depth examination of the gut microbiota in relation to satiety and provide insights into recent and future studies in this field.",

keywords = "CHAIN FATTY-ACIDS, GLUCAGON-LIKE PEPTIDE-1, PROTEIN-COUPLED RECEPTOR, ENTEROENDOCRINE L CELLS, WHOLE-GRAIN RYE, APPETITE REGULATION, METABOLIC SYNDROME, DIETARY FIBER, INTESTINAL BARRIER, INSULIN-SECRETION",

author = "J.J.A.J. Bastings and K. Venema and E.E. Blaak and T.C. Adam",

note = "Funding Information: J.B. is funded by the Horizon 2020 project 'SWEET' ( http://www.sweetproject.eu , 2018–2023, grant agreement 774293 ). Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

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doi = "10.1016/j.tem.2023.02.003",

language = "English",

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T1 - Influence of the gut microbiota on satiety signaling

AU - Bastings, J.J.A.J.

AU - Venema, K.

AU - Blaak, E.E.

AU - Adam, T.C.

PY - 2023/4/1

Y1 - 2023/4/1

N2 - Recent studies show a link between the gut microbiota and the regulation of satiety and energy intake, processes that contribute to the development and pathophysiol-ogy of metabolic diseases. However, this link is predominantly established in animal and in vitro studies, whereas human intervention studies are scarce. In this review we focus on recent evidence linking satiety and the gut microbiome, with specific emphasis on gut microbial short-chain fatty acids (SCFAs). Based on a systematic search we provide an overview of human studies linking the intake of prebiotics with gut microbial alterations and satiety signaling. Our outcomes highlight the importance of in-depth examination of the gut microbiota in relation to satiety and provide insights into recent and future studies in this field.

AB - Recent studies show a link between the gut microbiota and the regulation of satiety and energy intake, processes that contribute to the development and pathophysiol-ogy of metabolic diseases. However, this link is predominantly established in animal and in vitro studies, whereas human intervention studies are scarce. In this review we focus on recent evidence linking satiety and the gut microbiome, with specific emphasis on gut microbial short-chain fatty acids (SCFAs). Based on a systematic search we provide an overview of human studies linking the intake of prebiotics with gut microbial alterations and satiety signaling. Our outcomes highlight the importance of in-depth examination of the gut microbiota in relation to satiety and provide insights into recent and future studies in this field.

KW - CHAIN FATTY-ACIDS

KW - GLUCAGON-LIKE PEPTIDE-1

KW - PROTEIN-COUPLED RECEPTOR

KW - ENTEROENDOCRINE L CELLS

KW - WHOLE-GRAIN RYE

KW - APPETITE REGULATION

KW - METABOLIC SYNDROME

KW - DIETARY FIBER

KW - INTESTINAL BARRIER

KW - INSULIN-SECRETION

U2 - 10.1016/j.tem.2023.02.003

DO - 10.1016/j.tem.2023.02.003

M3 - (Systematic) Review article

C2 - 36870872

SN - 1043-2760

VL - 34

SP - 243

EP - 255

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 4

ER -

Influence of the gut microbiota on satiety signaling

Abstract

Keywords

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