Influence of the gut microbiota on satiety signaling

J.J.A.J. Bastings, K. Venema, E.E. Blaak*, T.C. Adam

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Recent studies show a link between the gut microbiota and the regulation of satiety and energy intake, processes that contribute to the development and pathophysiol-ogy of metabolic diseases. However, this link is predominantly established in animal and in vitro studies, whereas human intervention studies are scarce. In this review we focus on recent evidence linking satiety and the gut microbiome, with specific emphasis on gut microbial short-chain fatty acids (SCFAs). Based on a systematic search we provide an overview of human studies linking the intake of prebiotics with gut microbial alterations and satiety signaling. Our outcomes highlight the importance of in-depth examination of the gut microbiota in relation to satiety and provide insights into recent and future studies in this field.
Original languageEnglish
Pages (from-to)243-255
Number of pages13
JournalTrends in Endocrinology and Metabolism
Volume34
Issue number4
DOIs
Publication statusPublished - 1 Apr 2023

Keywords

  • CHAIN FATTY-ACIDS
  • GLUCAGON-LIKE PEPTIDE-1
  • PROTEIN-COUPLED RECEPTOR
  • ENTEROENDOCRINE L CELLS
  • WHOLE-GRAIN RYE
  • APPETITE REGULATION
  • METABOLIC SYNDROME
  • DIETARY FIBER
  • INTESTINAL BARRIER
  • INSULIN-SECRETION

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