Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study

L. K. Brahe*, L. Angquist, L.H. Larsen, K.S. Vimaleswaran, J. Hager, N. Viguerie, R.J. Loos, T. Handjieva-Darlenska, S.A. Jebb, P. Hlavaty, T.M. Larsen, J.A. Martinez, A. Papadaki, A.F. Pfeiffer, M.A. van Baak, T.I. Sorensen, C. Holst, D. Langin, A. Astrup, W.H. Saris

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0.26 mmol/l per A-allele/protein unit (95 % CI - 0.38, - 0.14, P= 0.000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.
Original languageEnglish
Pages (from-to)790-796
JournalBritish Journal of Nutrition
Issue number5
Publication statusPublished - 1 Jan 2013


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