TY - JOUR
T1 - Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study
AU - Brahe, L. K.
AU - Angquist, L.
AU - Larsen, L.H.
AU - Vimaleswaran, K.S.
AU - Hager, J.
AU - Viguerie, N.
AU - Loos, R.J.
AU - Handjieva-Darlenska, T.
AU - Jebb, S.A.
AU - Hlavaty, P.
AU - Larsen, T.M.
AU - Martinez, J.A.
AU - Papadaki, A.
AU - Pfeiffer, A.F.
AU - van Baak, M.A.
AU - Sorensen, T.I.
AU - Holst, C.
AU - Langin, D.
AU - Astrup, A.
AU - Saris, W.H.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0.26 mmol/l per A-allele/protein unit (95 % CI - 0.38, - 0.14, P= 0.000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.
AB - Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0.26 mmol/l per A-allele/protein unit (95 % CI - 0.38, - 0.14, P= 0.000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.
U2 - 10.1017/S0007114512006058
DO - 10.1017/S0007114512006058
M3 - Article
SN - 0007-1145
VL - 110
SP - 790
EP - 796
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 5
ER -