Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome

Nadine Mand; Ulrich Pecks; Matthias Hutten; Rolf Felix Maier; Mario Rüdiger; CRONOS Network

doi:10.1136/bmjpo-2024-003109

Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome

Nadine Mand^*, Ulrich Pecks, Matthias Hutten, Rolf Felix Maier, Mario Rüdiger, CRONOS Network

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

SARS-CoV-2 infection during pregnancy can adversely affect maternal and neonatal health, although risks vary depending on the variant of concern (VOC). Omicron, although highly infectious, causes fewer maternal and neonatal complications than earlier VOC, so vaccination may be considered unnecessary in planned pregnancy. Using data from the CRONOS registry, we compared pregnancy outcomes according to VOC and vaccination status. We found that vaccination during pregnancy reduced preterm birth rates compared with unvaccinated or vaccinated women with Omicron infection, without increasing severe neonatal outcomes. Given the risks associated with preterm birth, the study consistently supports vaccination recommendations for women planning pregnancy.

Original language	English
Article number	e003109
Journal	BMJ Paediatrics Open
Volume	9
Issue number	1
DOIs	https://doi.org/10.1136/bmjpo-2024-003109
Publication status	Published - 7 Jan 2025

Keywords

COVID-19
Neonatology
Adult
Female
Humans
Infant, Newborn
Pregnancy
COVID-19/prevention & control immunology epidemiology
COVID-19 Vaccines/administration & dosage adverse effects
Pregnancy Complications, Infectious/prevention & control virology
Pregnancy Outcome/epidemiology
Premature Birth/epidemiology
Registries
SARS-CoV-2/genetics
Vaccination

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10.1136/bmjpo-2024-003109Licence: CC BY-NC-ND

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title = "Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome",

abstract = "SARS-CoV-2 infection during pregnancy can adversely affect maternal and neonatal health, although risks vary depending on the variant of concern (VOC). Omicron, although highly infectious, causes fewer maternal and neonatal complications than earlier VOC, so vaccination may be considered unnecessary in planned pregnancy. Using data from the CRONOS registry, we compared pregnancy outcomes according to VOC and vaccination status. We found that vaccination during pregnancy reduced preterm birth rates compared with unvaccinated or vaccinated women with Omicron infection, without increasing severe neonatal outcomes. Given the risks associated with preterm birth, the study consistently supports vaccination recommendations for women planning pregnancy.",

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AU - Mand, Nadine

AU - Pecks, Ulrich

AU - Hutten, Matthias

AU - Maier, Rolf Felix

AU - Rüdiger, Mario

AU - CRONOS Network

PY - 2025/1/7

Y1 - 2025/1/7

N2 - SARS-CoV-2 infection during pregnancy can adversely affect maternal and neonatal health, although risks vary depending on the variant of concern (VOC). Omicron, although highly infectious, causes fewer maternal and neonatal complications than earlier VOC, so vaccination may be considered unnecessary in planned pregnancy. Using data from the CRONOS registry, we compared pregnancy outcomes according to VOC and vaccination status. We found that vaccination during pregnancy reduced preterm birth rates compared with unvaccinated or vaccinated women with Omicron infection, without increasing severe neonatal outcomes. Given the risks associated with preterm birth, the study consistently supports vaccination recommendations for women planning pregnancy.

AB - SARS-CoV-2 infection during pregnancy can adversely affect maternal and neonatal health, although risks vary depending on the variant of concern (VOC). Omicron, although highly infectious, causes fewer maternal and neonatal complications than earlier VOC, so vaccination may be considered unnecessary in planned pregnancy. Using data from the CRONOS registry, we compared pregnancy outcomes according to VOC and vaccination status. We found that vaccination during pregnancy reduced preterm birth rates compared with unvaccinated or vaccinated women with Omicron infection, without increasing severe neonatal outcomes. Given the risks associated with preterm birth, the study consistently supports vaccination recommendations for women planning pregnancy.

KW - COVID-19

KW - Neonatology

KW - Adult

KW - Female

KW - Humans

KW - Infant, Newborn

KW - Pregnancy

KW - COVID-19/prevention & control immunology epidemiology

KW - COVID-19 Vaccines/administration & dosage adverse effects

KW - Pregnancy Complications, Infectious/prevention & control virology

KW - Pregnancy Outcome/epidemiology

KW - Premature Birth/epidemiology

KW - Registries

KW - SARS-CoV-2/genetics

KW - Vaccination

U2 - 10.1136/bmjpo-2024-003109

DO - 10.1136/bmjpo-2024-003109

M3 - Article

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JO - BMJ Paediatrics Open

JF - BMJ Paediatrics Open

IS - 1

M1 - e003109

ER -

Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome

Abstract

Keywords

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