Influence of paternal age on ongoing pregnancy rate at eight weeks' gestation in assisted reproduction

Aukje Marieke Meijerink; Liliana Ramos; Kathrin Fleischer; Joris A. Veltman; Jan C. Hendriks; Didi D. Braat

doi:10.1016/j.rbmo.2015.09.017

Influence of paternal age on ongoing pregnancy rate at eight weeks' gestation in assisted reproduction

Aukje Marieke Meijerink^*, Liliana Ramos, Kathrin Fleischer, Joris A. Veltman, Jan C. Hendriks, Didi D. Braat

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A retrospective cohort study was performed with the followings aims: to evaluate the influence of paternal age on best embryo quality available for embryo transfer on the third day; biochemical pregnancy rate; miscarriage rate and ongoing pregnancy rate at 8 weeks' gestational age, after IVF or intracytoplasmic sperm injection (ICSI) treatment, respectively, including treatment with non-ejaculated spermatozoa. In total, 7051 first IVF/ICSI cycles in Radboud university medical center, between 1 January 2001 and 1 June 2013 were included in this study. A statistical model was used to analyse the effect of paternal age and maternal age. No statistically significant differences between the paternal age groups were found with respect to the probability of an ongoing pregnancy after the first cycle (35-44 years: odds ratio [OR] = 0.97 [95% confidence interval [CI]: 0.86 to 1.10] and ?45 years: OR = 1.01 [95% CI: 0.82 to 1.26]), respectively, compared with

Original language	English
Pages (from-to)	96-103
Journal	Reproductive Biomedicine Online
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.rbmo.2015.09.017
Publication status	Published - Jan 2016

Keywords

assisted reproductive techniques
male infertility
paternal age
pregnancy rate
semen
spermatozoa

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10.1016/j.rbmo.2015.09.017

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@article{5b79cf39a74e47848c8891216f7eaa5e,

title = "Influence of paternal age on ongoing pregnancy rate at eight weeks' gestation in assisted reproduction",

abstract = "A retrospective cohort study was performed with the followings aims: to evaluate the influence of paternal age on best embryo quality available for embryo transfer on the third day; biochemical pregnancy rate; miscarriage rate and ongoing pregnancy rate at 8 weeks' gestational age, after IVF or intracytoplasmic sperm injection (ICSI) treatment, respectively, including treatment with non-ejaculated spermatozoa. In total, 7051 first IVF/ICSI cycles in Radboud university medical center, between 1 January 2001 and 1 June 2013 were included in this study. A statistical model was used to analyse the effect of paternal age and maternal age. No statistically significant differences between the paternal age groups were found with respect to the probability of an ongoing pregnancy after the first cycle (35-44 years: odds ratio [OR] = 0.97 [95% confidence interval [CI]: 0.86 to 1.10] and ?45 years: OR = 1.01 [95% CI: 0.82 to 1.26]), respectively, compared with ",

keywords = "assisted reproductive techniques, male infertility, paternal age, pregnancy rate, semen, spermatozoa",

author = "Meijerink, {Aukje Marieke} and Liliana Ramos and Kathrin Fleischer and Veltman, {Joris A.} and Hendriks, {Jan C.} and Braat, {Didi D.}",

year = "2016",

month = jan,

doi = "10.1016/j.rbmo.2015.09.017",

language = "English",

volume = "32",

pages = "96--103",

journal = "Reproductive Biomedicine Online",

issn = "1472-6483",

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T1 - Influence of paternal age on ongoing pregnancy rate at eight weeks' gestation in assisted reproduction

AU - Meijerink, Aukje Marieke

AU - Ramos, Liliana

AU - Fleischer, Kathrin

AU - Veltman, Joris A.

AU - Hendriks, Jan C.

AU - Braat, Didi D.

PY - 2016/1

Y1 - 2016/1

N2 - A retrospective cohort study was performed with the followings aims: to evaluate the influence of paternal age on best embryo quality available for embryo transfer on the third day; biochemical pregnancy rate; miscarriage rate and ongoing pregnancy rate at 8 weeks' gestational age, after IVF or intracytoplasmic sperm injection (ICSI) treatment, respectively, including treatment with non-ejaculated spermatozoa. In total, 7051 first IVF/ICSI cycles in Radboud university medical center, between 1 January 2001 and 1 June 2013 were included in this study. A statistical model was used to analyse the effect of paternal age and maternal age. No statistically significant differences between the paternal age groups were found with respect to the probability of an ongoing pregnancy after the first cycle (35-44 years: odds ratio [OR] = 0.97 [95% confidence interval [CI]: 0.86 to 1.10] and ?45 years: OR = 1.01 [95% CI: 0.82 to 1.26]), respectively, compared with

AB - A retrospective cohort study was performed with the followings aims: to evaluate the influence of paternal age on best embryo quality available for embryo transfer on the third day; biochemical pregnancy rate; miscarriage rate and ongoing pregnancy rate at 8 weeks' gestational age, after IVF or intracytoplasmic sperm injection (ICSI) treatment, respectively, including treatment with non-ejaculated spermatozoa. In total, 7051 first IVF/ICSI cycles in Radboud university medical center, between 1 January 2001 and 1 June 2013 were included in this study. A statistical model was used to analyse the effect of paternal age and maternal age. No statistically significant differences between the paternal age groups were found with respect to the probability of an ongoing pregnancy after the first cycle (35-44 years: odds ratio [OR] = 0.97 [95% confidence interval [CI]: 0.86 to 1.10] and ?45 years: OR = 1.01 [95% CI: 0.82 to 1.26]), respectively, compared with

KW - assisted reproductive techniques

KW - male infertility

KW - paternal age

KW - pregnancy rate

KW - semen

KW - spermatozoa

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DO - 10.1016/j.rbmo.2015.09.017

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JF - Reproductive Biomedicine Online

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Influence of paternal age on ongoing pregnancy rate at eight weeks' gestation in assisted reproduction

Abstract

Keywords

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